2uyt
From Proteopedia
(New page: 200px<br /> <applet load="2uyt" size="450" color="white" frame="true" align="right" spinBox="true" caption="2uyt, resolution 1.55Å" /> '''STRUCTURE OF L-RHAM...) |
|||
| Line 8: | Line 8: | ||
==About this Structure== | ==About this Structure== | ||
| - | 2UYT is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]] with LRH and ADP as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.5 2.7.1.5]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2UYT OCA]]. | + | 2UYT is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]] with LRH and ADP as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/Rhamnulokinase Rhamnulokinase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.5 2.7.1.5]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2UYT OCA]]. |
==Reference== | ==Reference== | ||
Substrate spectrum of L-rhamnulose kinase related to models derived from two ternary complex structures., Grueninger D, Schulz GE, FEBS Lett. 2007 Jun 26;581(16):3127-30. Epub 2007 Jun 6. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17568582 17568582] | Substrate spectrum of L-rhamnulose kinase related to models derived from two ternary complex structures., Grueninger D, Schulz GE, FEBS Lett. 2007 Jun 26;581(16):3127-30. Epub 2007 Jun 6. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17568582 17568582] | ||
[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
| + | [[Category: Rhamnulokinase]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Grueninger, D.]] | [[Category: Grueninger, D.]] | ||
| Line 28: | Line 29: | ||
[[Category: transferase]] | [[Category: transferase]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 12:03:49 2007'' |
Revision as of 09:59, 30 October 2007
|
STRUCTURE OF L-RHAMNULOSE KINASE IN COMPLEX WITH ADP AND BETA-L-RHAMNULOSE.
Overview
The enzyme L-rhamnulose kinase from Escherichia coli participates in the, degradation pathway of L-rhamnose, a common natural deoxy-hexose. The, structure of the enzyme in a ternary complex with its substrates ADP and, L-rhamnulose has been determined at 1.55A resolution and refined to, R(cryst)/R(free) values of 0.179/0.209. The result was compared with the, lower resolution structure of a corresponding complex containing, L-fructose instead of L-rhamnulose. In light of the two established sugar, positions and conformations, a number of rare sugars have been modeled, into the active center of L-rhamnulose kinase and the model structures, have been compared with the known enzymatic phosphorylation rates. Rare, sugars are of rising interest for the synthesis of bioactive compounds.
About this Structure
2UYT is a [Single protein] structure of sequence from [Escherichia coli] with LRH and ADP as [ligands]. Active as [Rhamnulokinase], with EC number [2.7.1.5]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Substrate spectrum of L-rhamnulose kinase related to models derived from two ternary complex structures., Grueninger D, Schulz GE, FEBS Lett. 2007 Jun 26;581(16):3127-30. Epub 2007 Jun 6. PMID:17568582
Page seeded by OCA on Tue Oct 30 12:03:49 2007
