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Ephrin receptor

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== 3D Structures of ephrin receptors ==
== 3D Structures of ephrin receptors ==
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===Ephrin A1 receptor===
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[[3kka]] - hEPH A1 SAM+ hEPH A2 SAM – human<BR />
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[[2k1l]] - hEPH A1 transmembrane domain – NMR<BR />
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[[1x5a]] - hEPH A1 fn3 domain – NMR<BR />
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===Ephrin A2 receptor===
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[[3hpn]], [[3c8x]] - hEPH A2 LBD<BR />
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[[2x10]], [[3fl7]] - hEPH A2 ectodomain<BR />
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[[2k9y]], [[3e8n]] - hEPH A2 transmembrane domain – NMR<BR />
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[[1mqb]] - hEPH A2 kinase domain<BR />
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[[3mx0]], [[1x11]] - hEPH A2 ectodomain + ephrin A5<BR />
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[[3hei]], [[3czu]] - hEPH A2 LBD + ephrin A1<BR />
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[[3mbw]] - hEPH A2 LBD + carbohydrate-recognition domain + ephrin A1
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===Ephrin A3 receptor===
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[[2qo2]], [[2qob]], [[2gsf]] - hEPH A3 kinase domain<BR />
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[[2qok]], [[2qol]], [[2qon]], [[2qoo]], [[2qod]], [[2qof]], [[2qoi]] - hEPH A3 kinase domain (mutant) <BR />
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[[3fxx]], [[3fy2]] – hEPH A3 kinase domain + peptide substrate<BR />
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[[2qoq]], [[2qo7]], [[2qo9]], [[2qoc]] - hEPH A3 kinase domain + AMP-PNP<BR />
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[[3dzq]] - hEPH A3 kinase domain + inhibitor
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===Ephrin A4 receptor===
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[[2wo1]], [[3ckh]] - hEPH A4 LBD<BR />
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[[2wo3]] - hEPH A4 LBD + ephrin A2 receptor-binding domain<BR />
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[[2wo2]], [[3gxu]] - hEPH A4 LBD + ephrin B2 receptor-binding domain
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===Ephrin A5 receptor===
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[[2r2p]] - hEPH A5 kinase domain<BR />
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[[1shx]] - mEPH A5 – mouse
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===Ephrin A7 receptor===
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[[3nru]] – hEPH A7 LBD<BR />
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[[3h8m]] – hEPH A7 SAM<BR />
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[[2rei]] - hEPH A7 kinase domain<BR />
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[[3dko]] – hEPH A7 kinase domain + inhibitor
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===Ephrin A8 receptor===
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[[3kul]] - hEPH A8 kinase domain<BR />
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[[1x5l]] – hEPH A8 fn3 domain – NMR<BR />
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[[1ucv]] - hEPH A8 SAM – NMR<BR />
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===Ephrin B1 receptor===
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[[2eao]] – hEPH B1 SAM – NMR<BR />
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[[2djs]] - hEPH B1 fn3 domain – NMR<BR />
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===Ephrin B2 receptor===
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[[3etp]] – hEPH B2<BR />
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[[1f0m]] – mEPH B2 SAM<BR />
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[[1sgg]] - mEPH B2 SAM – chicken - NMR<BR />
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[[2vsk]], [[2vsm]] – hEPH B2 + Viral Hemagglutinin-neuraminidase<BR />
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[[2qbx]] – hEPH B2 + peptide agonist<BR />
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[[2hen]] - hEPH B2 kinase domain + ADP<BR />
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[[1shw]] - mEPH B2 LBD + ephrin A5<BR />
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[[1kgy]] - mEPH B2 LBD + ephrin B2 extracellular domain<BR />
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[[1iko]] - mEPH B2 ectodomain
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===Ephrin B3 receptor===
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[[3p1i]] – hEPH B3 LBD<BR />
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===Ephrin B4 receptor===
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[[2qkq]] – hEPH B4 SAM<BR />
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[[2e7h]] – hEPH B4 fn3 domain - NMR<BR />
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[[2x9f]] - hEPH B4 kinase domain (mutant) <BR />
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[[2vwx]], [[2vwz]], [[2vx0]], [[2vx1]], [[2vwu]], [[2vwv]], [[2vww]] – hEPH B4 + inhibitor <BR />
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[[2hle]], [[2bba]] - hEPH B4 LBD + ephrin B2
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[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 11:13, 29 May 2011

Image:3hei.png
Crystal Structure of ephrin receptor, 3hei

Template:STRUCTURE 3hei

Ephrin receptors (EPH) are components of the cell signaling pathways. They belong to the receptor tyrosine kinases. The extracellular ligand-binding domain (LBD) interacts with ephrin. EPH contains a sterile-α-motif (SAM) domain and a second fibronectin III domain (fn3).

Contents



3D Structures of ephrin receptors

Ephrin A1 receptor

3kka - hEPH A1 SAM+ hEPH A2 SAM – human
2k1l - hEPH A1 transmembrane domain – NMR
1x5a - hEPH A1 fn3 domain – NMR

Ephrin A2 receptor

3hpn, 3c8x - hEPH A2 LBD
2x10, 3fl7 - hEPH A2 ectodomain
2k9y, 3e8n - hEPH A2 transmembrane domain – NMR
1mqb - hEPH A2 kinase domain
3mx0, 1x11 - hEPH A2 ectodomain + ephrin A5
3hei, 3czu - hEPH A2 LBD + ephrin A1
3mbw - hEPH A2 LBD + carbohydrate-recognition domain + ephrin A1

Ephrin A3 receptor

2qo2, 2qob, 2gsf - hEPH A3 kinase domain
2qok, 2qol, 2qon, 2qoo, 2qod, 2qof, 2qoi - hEPH A3 kinase domain (mutant)
3fxx, 3fy2 – hEPH A3 kinase domain + peptide substrate
2qoq, 2qo7, 2qo9, 2qoc - hEPH A3 kinase domain + AMP-PNP
3dzq - hEPH A3 kinase domain + inhibitor

Ephrin A4 receptor

2wo1, 3ckh - hEPH A4 LBD
2wo3 - hEPH A4 LBD + ephrin A2 receptor-binding domain
2wo2, 3gxu - hEPH A4 LBD + ephrin B2 receptor-binding domain

Ephrin A5 receptor

2r2p - hEPH A5 kinase domain
1shx - mEPH A5 – mouse

Ephrin A7 receptor

3nru – hEPH A7 LBD
3h8m – hEPH A7 SAM
2rei - hEPH A7 kinase domain
3dko – hEPH A7 kinase domain + inhibitor

Ephrin A8 receptor

3kul - hEPH A8 kinase domain
1x5l – hEPH A8 fn3 domain – NMR
1ucv - hEPH A8 SAM – NMR

Ephrin B1 receptor

2eao – hEPH B1 SAM – NMR
2djs - hEPH B1 fn3 domain – NMR

Ephrin B2 receptor

3etp – hEPH B2
1f0m – mEPH B2 SAM
1sgg - mEPH B2 SAM – chicken - NMR
2vsk, 2vsm – hEPH B2 + Viral Hemagglutinin-neuraminidase
2qbx – hEPH B2 + peptide agonist
2hen - hEPH B2 kinase domain + ADP
1shw - mEPH B2 LBD + ephrin A5
1kgy - mEPH B2 LBD + ephrin B2 extracellular domain
1iko - mEPH B2 ectodomain

Ephrin B3 receptor

3p1i – hEPH B3 LBD

Ephrin B4 receptor

2qkq – hEPH B4 SAM
2e7h – hEPH B4 fn3 domain - NMR
2x9f - hEPH B4 kinase domain (mutant)
2vwx, 2vwz, 2vx0, 2vx1, 2vwu, 2vwv, 2vww – hEPH B4 + inhibitor
2hle, 2bba - hEPH B4 LBD + ephrin B2

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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