1uyu

From Proteopedia

Revision as of 09:59, 30 October 2007

XENON COMPLEX OF WILDTYPE P450CAM FROM PSEUDOMONAS PUTIDA

Overview

In cytochrome P450s, the active site is situated deep inside the protein, next to the heme cofactor, and is often completely isolated from the, surrounding solvent. To identify routes by which substrates may enter into, and products exit from the active site, random expulsion molecular, dynamics simulations were performed for three cytochrome P450s: CYP101, CYP102A1 and CYP107A1 [J. Mol. Biol. 303 (2000) 797; Proc. Natl. Acad., Sci. USA 99 (2002) 5361]. Amongst the different pathways identified, one, pathway was found to be common to all three cytochrome P450s although the, mechanism of ligand passage along it was different in each case and, apparently adapted to the substrate specificity of the enzyme. Recently, a, number of new crystal structures of cytochrome P450s have been solved., ... [(full description)]

About this Structure

1UYU is a [Single protein] structure of sequence from [Pseudomonas putida] with K, HEM, CAM and XE as [ligands]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].

Reference

A survey of active site access channels in cytochromes P450., Wade RC, Winn PJ, Schlichting I, Sudarko, J Inorg Biochem. 2004 Jul;98(7):1175-82. PMID:15219983

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