2d47
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(New page: 200px<br /><applet load="2d47" size="350" color="white" frame="true" align="right" spinBox="true" caption="2d47, resolution 2.000Å" /> '''MOLECULAR STRUCTURE...)
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Revision as of 16:54, 29 January 2008
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MOLECULAR STRUCTURE OF A COMPLETE TURN OF A-DNA
Overview
We have determined the crystal structure of the dodecamer d(CCCCCGCGGGGG), showing for the first time a complete turn of A-DNA. It has average, structural parameters similar to those determined in fibres. Nevertheless, it shows a considerable local variation in structure which is in part, associated with the presence of a bound spermine molecule. We conclude, that the local DNA conformation does not only depend on the base sequence, but may be strongly modified upon interaction with other molecules. In, particular, the CpG sequence, which is found in hypersensitive regions of, the genome, appears to be able to easily change its conformation under, external influences.
About this Structure
2D47 is a Protein complex structure of sequences from [1] with as ligand. Full crystallographic information is available from OCA.
Reference
Molecular structure of a complete turn of A-DNA., Verdaguer N, Aymami J, Fernandez-Forner D, Fita I, Coll M, Huynh-Dinh T, Igolen J, Subirana JA, J Mol Biol. 1991 Sep 20;221(2):623-35. PMID:1920437
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