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2d4r

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(New page: 200px<br /><applet load="2d4r" size="350" color="white" frame="true" align="right" spinBox="true" caption="2d4r, resolution 2.40&Aring;" /> '''Crystal structure of...)
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Revision as of 16:55, 29 January 2008

Image:2d4r.gif

2d4r, resolution 2.40Å

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Crystal structure of TTHA0849 from Thermus thermophilus HB8

Overview

The crystal structure of a conserved hypothetical protein, TTHA0849 from, Thermus thermophilus HB8, has been determined at 2.4 A resolution as a, part of a structural and functional genomics project on T. thermophilus, HB8. The main-chain folding shows a compact alpha+beta motif, forming a, hydrophobic cavity in the molecule. A structural similarity search reveals, that it resembles those steroidogenic acute regulatory proteins that, contain the lipid-transfer (START) domain, even though TTHA0849 shows, comparatively weak sequence identity to polyketide cyclases. However, the, size of the ligand-binding cavity is distinctly smaller than other START, domain-containing proteins, suggesting that it catalyses the transfer of, smaller ligand molecules.

About this Structure

2D4R is a Single protein structure of sequence from Thermus thermophilus with as ligand. Full crystallographic information is available from OCA.

Reference

Structure of a conserved hypothetical protein, TTHA0849 from Thermus thermophilus HB8, at 2.4 A resolution: a putative member of the StAR-related lipid-transfer (START) domain superfamily., Nakabayashi M, Shibata N, Komori H, Ueda Y, Iino H, Ebihara A, Kuramitsu S, Higuchi Y, Acta Crystallograph Sect F Struct Biol Cryst Commun. 2005 Dec 1;61(Pt, 12):1027-31. Epub 2005 Nov 5. PMID:16511226

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