2d94
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(New page: 200px<br /><applet load="2d94" size="350" color="white" frame="true" align="right" spinBox="true" caption="2d94, resolution 1.700Å" /> '''THE CONFORMATION OF...)
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Revision as of 16:57, 29 January 2008
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THE CONFORMATION OF THE DNA DOUBLE HELIX IN THE CRYSTAL IS DEPENDENT ON ITS ENVIRONMENT
Overview
Studies of the crystal structures of more than 30 synthetic DNA fragments, have provided structural information about three basic forms of the double, helix: A-, B- and Z-form DNA. These studies have demonstrated that the DNA, double helix adopts a highly variable structure which is related to its, base sequence. The extent to which such observed structures are influenced, by the crystalline environment can be found by studying the same molecule, in different crystalline forms. We have recently crystallized one, particular oligomer in various crystal forms. Here we report the results, of structural analyses of the different crystal structures and demonstrate, that the DNA double helix can adopt a range of conformations in the, crystalline state depending on hydration, molecular packing and, temperature. These results have implications on our understanding of the, influence of the environment on DNA structure, and on the modes of DNA, recognition by proteins.
About this Structure
2D94 is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
Reference
The conformation of the DNA double helix in the crystal is dependent on its environment., Shakked Z, Guerstein-Guzikevich G, Eisenstein M, Frolow F, Rabinovich D, Nature. 1989 Nov 23;342(6248):456-60. PMID:2586615
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