1w4v
From Proteopedia
(New page: 200px<br /> <applet load="1w4v" size="450" color="white" frame="true" align="right" spinBox="true" caption="1w4v, resolution 1.80Å" /> '''STRUCTURE OF THE OX...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1W4V is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1W4V OCA]]. | + | 1W4V is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]]. Structure known Active Site: TRX. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1W4V OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: thioredoxin]] | [[Category: thioredoxin]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 12:07:27 2007'' |
Revision as of 10:02, 30 October 2007
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STRUCTURE OF THE OXIDISED FORM OF HUMAN THIOREDOXIN 2
Overview
Mammalian thioredoxin 2 is a mitochondrial isoform of highly evolutionary, conserved thioredoxins. Thioredoxins are small ubiquitous, protein-disulfide oxidoreductases implicated in a large variety of, biological functions. In mammals, thioredoxin 2 is encoded by a nuclear, gene and is targeted to mitochondria by a N-terminal mitochondrial, presequence. Recently, mitochondrial thioredoxin 2 was shown to interact, with components of the mitochondrial respiratory chain and to play a role, in the control of mitochondrial membrane potential, regulating, mitochondrial apoptosis signaling pathway. Here we report the first, crystal structures of a mammalian mitochondrial thioredoxin 2. Crystal, forms of reduced and oxidized human thioredoxin 2 are described at 2.0 and, 1.8 A resolution. Though ... [(full description)]
About this Structure
1W4V is a [Single protein] structure of sequence from [Homo sapiens]. Structure known Active Site: TRX. Full crystallographic information is available from [OCA].
Reference
Crystal structures of oxidized and reduced forms of human mitochondrial thioredoxin 2., Smeets A, Evrard C, Landtmeters M, Marchand C, Knoops B, Declercq JP, Protein Sci. 2005 Oct;14(10):2610-21. PMID:16195549
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