1hsr
From Proteopedia
(New page: 200px<br /> <applet load="1hsr" size="450" color="white" frame="true" align="right" spinBox="true" caption="1hsr, resolution 1.60Å" /> '''BINDING MODE OF BEN...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1HSR is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/ ]] with CA, HEM and BHO as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.7 1.11.1.7]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1HSR OCA]]. | + | 1HSR is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Eukaryota Eukaryota]] with CA, HEM and BHO as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/Peroxidase Peroxidase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.7 1.11.1.7]]. Structure known Active Sites: CA1, CA2 and GL1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1HSR OCA]]. |
==Reference== | ==Reference== | ||
Binding mode of benzhydroxamic acid to Arthromyces ramosus peroxidase shown by X-ray crystallographic analysis of the complex at 1.6 A resolution., Itakura H, Oda Y, Fukuyama K, FEBS Lett. 1997 Jul 21;412(1):107-10. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9257700 9257700] | Binding mode of benzhydroxamic acid to Arthromyces ramosus peroxidase shown by X-ray crystallographic analysis of the complex at 1.6 A resolution., Itakura H, Oda Y, Fukuyama K, FEBS Lett. 1997 Jul 21;412(1):107-10. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9257700 9257700] | ||
| + | [[Category: Eukaryota]] | ||
| + | [[Category: Peroxidase]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Fukuyama, K.]] | [[Category: Fukuyama, K.]] | ||
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[[Category: peroxidase]] | [[Category: peroxidase]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 12:07:39 2007'' |
Revision as of 10:02, 30 October 2007
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BINDING MODE OF BENZHYDROXAMIC ACID TO ARTHROMYCES RAMOSUS PEROXIDASE
Overview
The crystal structure of Arthromyces ramosus peroxidase (ARP) in complex, with benzhydroxamic acid (BHA) as determined by X-ray analysis at 1.6 A, shows unambiguously how BHA binds to ARP. BHA is located in the distal, heme pocket. Its functional groups are held by three hydrogen bonds to, His56N(epsilon), Arg52N(epsilon), and Pro(154)O, but are too far away to, interact with the heme iron. The aromatic ring of BHA is positioned at the, entrance of the channel to the heme pocket, approximately parallel to the, heme group. Most water molecules at the active site of the native enzyme, are replaced by BHA, leaving a ligand, probably a water molecule, at the, sixth position of the heme. Results are compared with spectroscopic data.
About this Structure
1HSR is a [Single protein] structure of sequence from [Eukaryota] with CA, HEM and BHO as [ligands]. Active as [Peroxidase], with EC number [1.11.1.7]. Structure known Active Sites: CA1, CA2 and GL1. Full crystallographic information is available from [OCA].
Reference
Binding mode of benzhydroxamic acid to Arthromyces ramosus peroxidase shown by X-ray crystallographic analysis of the complex at 1.6 A resolution., Itakura H, Oda Y, Fukuyama K, FEBS Lett. 1997 Jul 21;412(1):107-10. PMID:9257700
Page seeded by OCA on Tue Oct 30 12:07:39 2007
Categories: Eukaryota | Peroxidase | Single protein | Fukuyama, K. | Itakura, H. | BHO | CA | HEM | Glycoprotein | Oxidoreductase
