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2f9u
From Proteopedia
OCA (Talk | contribs)
(New page: 200px<br /><applet load="2f9u" size="350" color="white" frame="true" align="right" spinBox="true" caption="2f9u, resolution 2.60Å" /> '''HCV NS3 protease dom...)
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Revision as of 17:31, 29 January 2008
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HCV NS3 protease domain with NS4a peptide and a ketoamide inhibitor with a P2 norborane
Overview
Prolonged hepatitis C infection is the leading cause for cirrhosis of the, liver and hepatocellular carcinoma. The etiological agent HCV virus codes, a single polyprotein of approximately 3000 amino acids that is processed, with the help of a serine protease NS3A to produce structural and, non-structural proteins required for viral replication. Inhibition of NS3, protease can potentially be used to develop drugs for treatment of HCV, infections. Herein, we report the development of a series of novel NS3, serine protease inhibitors derived from 2-aza-bicyclo[2.2.1]-heptane, carboxylic acid with potential therapeutic use for treatment of HCV, infections.
About this Structure
2F9U is a Protein complex structure of sequences from Hepatitis c virus with and as ligands. Full crystallographic information is available from OCA.
Reference
Novel inhibitors of hepatitis C NS3-NS4A serine protease derived from 2-aza-bicyclo[2.2.1]heptane-3-carboxylic acid., Venkatraman S, Njoroge FG, Wu W, Girijavallabhan V, Prongay AJ, Butkiewicz N, Pichardo J, Bioorg Med Chem Lett. 2006 Mar 15;16(6):1628-32. Epub 2006 Jan 18. PMID:16413182
Page seeded by OCA on Tue Jan 29 19:31:30 2008
