Neurexin
From Proteopedia
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== 3D Structures of Neurexin == | == 3D Structures of Neurexin == | ||
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Revision as of 10:28, 16 June 2011
Neurexins (NRXN) are a family of presynaptic proteins which bind to the postsynaptic Neuroligin (NLGN) to form a complex which attaches neurons. The NRXN family contains 4 members which are numbered 1 to 4. The α-NRXN contains 6 homologous LNS domains while the β-NRXN contains only LNS6. The images at the left and at the right correspond to one representative NRXN, i.e. the crystal structure of mouse β-neurexin 1 (3bod).
For Structural Analysis of Neurexin, See: Neuroligin-Neurexin Interaction
3D Structures of Neurexin
Update June 2011
α-NRXN
2h0b - bα-NRXN-1 LNS2 – bovine
2r16 - bα-NRXN-1 LNS 4
β-NRXN
3mw2 – mβ-NRXN-1 +splice insert 4 – mouse
3bod - mβ-NRXN-1
3bop - mβ-NRXN-2d4
3mw3, 2r1b - rβ-NRXN-2 +splice insert 4 – rat
2r1b - rβ-NRXN-1 +splice insert 4
2r1d - rβ-NRXN-1 +Ca
1c4r - rβ-NRXN-1
3mw4 - mβ-NRXN-3
NRXN+NLGN
2xb6, 2wqz – rβ-NRXN-1 +hNLGN-4 cholinesterase domain
3b3q - hNRXN-1 LNS domain+mNLGN-1 cholinesterase domain
3biw - rβ-NRXN-1 +rNLGN-1 cholinesterase domain
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Alexander Berchansky, David Canner, Joel L. Sussman, Jaime Prilusky
