Neurexin
From Proteopedia
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| - | [[Image:3bod.png|left|200px|thumb|Crystal Structure of mouse neurexin 1 [[3bod]]]] | + | [[Image:3bod.png|left|200px|thumb|Crystal Structure of mouse neurexin 1 ([[3bod]])]] |
| - | {{STRUCTURE_3bod| PDB=3bod | SIZE=300| SCENE=Neurexin/Cv/1 |right|CAPTION=Mouse neurexin 1 [[3bod]] }} | + | {{STRUCTURE_3bod| PDB=3bod | SIZE=300| SCENE=Neurexin/Cv/1 |right|CAPTION=Mouse neurexin 1 ([[3bod]]) }} |
[[Neurexin|Neurexins]] (NRXN) are a family of presynaptic proteins which bind to the postsynaptic [[Neuroligin]] (NLGN) to form a complex which attaches neurons. The NRXN family contains 4 members which are numbered 1 to 4. The NRXN-α contains 6 homologous LNS domains while the NRXN-β contains only LNS6. | [[Neurexin|Neurexins]] (NRXN) are a family of presynaptic proteins which bind to the postsynaptic [[Neuroligin]] (NLGN) to form a complex which attaches neurons. The NRXN family contains 4 members which are numbered 1 to 4. The NRXN-α contains 6 homologous LNS domains while the NRXN-β contains only LNS6. | ||
Revision as of 11:12, 16 June 2011
Neurexins (NRXN) are a family of presynaptic proteins which bind to the postsynaptic Neuroligin (NLGN) to form a complex which attaches neurons. The NRXN family contains 4 members which are numbered 1 to 4. The NRXN-α contains 6 homologous LNS domains while the NRXN-β contains only LNS6.
For Structural Analysis of Neurexin, See: Neuroligin-Neurexin Interaction
3D Structures of Neurexin
Update June 2011
NRXN
3mw2 – mNRXN-1α LNS domain+splice insert 4 – mouse
3bod, 3bop - mNRXN-1α LNS domain
3mw3, 2r1b - rNRXN-1α LNS domain+splice insert 4 – rat
2r16 - rNRXN-1α LNS domain+Ca
1c4r - rNRXN-1α LNS domain
3mw4 - mNRXN-1α LNS domain
2h0b - bNRXN-1α LNS2 domain – bovine
3asi - bNRXN-1α LNS25-EGF3-LNS6 domains
NRXN+NLGN
2xb6, 2wqz – rNRXN-1α LNS domain +hNLGN-4 cholinesterase domain
3b3q - hNRXN-1α LNS domain+mNLGN-4 cholinesterase domain
3biw - rNRXN-1α LNS domain+rNLGN-1 cholinesterase domain
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Alexander Berchansky, David Canner, Joel L. Sussman, Jaime Prilusky
