3s2v

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'''Unreleased structure'''
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[[Image:3s2v.jpg|left|200px]]
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The entry 3s2v is ON HOLD
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{{STRUCTURE_3s2v| PDB=3s2v | SCENE= }}
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Authors: Venskutonyte, R., Frydenvang, K., Kastrup, J.S.
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===Crystal Structure of the Ligand Binding Domain of GluK1 in Complex with an Antagonist (S)-1-(2'-Amino-2'-carboxyethyl)-3-[(2-carboxythien-3-yl)methyl]thieno[3,4-d]pyrimidin-2,4-dione at 2.5 A Resolution===
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Description: Crystal Structure of the Ligand Binding Domain of GluK1 in Complex with an Antagonist (S)-1-(2'-Amino-2'-carboxyethyl)-3-[(2-carboxythien-3-yl)methyl]thieno[3,4-d]pyrimidin-2,4-dione at 2.5 A Resolution
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{{ABSTRACT_PUBMED_21619066}}
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==About this Structure==
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[[3s2v]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S2V OCA].
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==Reference==
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<ref group="xtra">PMID:021619066</ref><ref group="xtra">PMID:015710405</ref><references group="xtra"/>
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[[Category: Rattus norvegicus]]
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[[Category: Frydenvang, K.]]
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[[Category: Kastrup, J S.]]
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[[Category: Venskutonyte, R.]]
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[[Category: Antagonist]]
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[[Category: Ionotropic glutamate receptor]]
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[[Category: Membrane protein]]

Revision as of 16:40, 22 June 2011

Image:3s2v.jpg

Template:STRUCTURE 3s2v

Crystal Structure of the Ligand Binding Domain of GluK1 in Complex with an Antagonist (S)-1-(2'-Amino-2'-carboxyethyl)-3-[(2-carboxythien-3-yl)methyl]thieno[3,4-d]pyrimidin-2,4-dione at 2.5 A Resolution

Template:ABSTRACT PUBMED 21619066

About this Structure

3s2v is a 2 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

  • Venskutonyte R, Butini S, Sanna Coccone S, Gemma S, Brindisi M, Kumar V, Guarino E, Maramai S, Valenti S, Amir A, Valades EA, Frydenvang K, Kastrup JS, Novellino E, Campiani G, Pickering DS. Selective Kainate Receptor (GluK1) Ligands Structurally Based upon 1H-Cyclopentapyrimidin-2,4(1H,3H)-dione: Synthesis, Molecular Modeling, and Pharmacological and Biostructural Characterization. J Med Chem. 2011 Jun 13. PMID:21619066 doi:10.1021/jm2004078
  • Naur P, Vestergaard B, Skov LK, Egebjerg J, Gajhede M, Kastrup JS. Crystal structure of the kainate receptor GluR5 ligand-binding core in complex with (S)-glutamate. FEBS Lett. 2005 Feb 14;579(5):1154-60. PMID:15710405 doi:10.1016/j.febslet.2005.01.012

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