2ivd
From Proteopedia
(New page: 200px<br /> <applet load="2ivd" size="450" color="white" frame="true" align="right" spinBox="true" caption="2ivd, resolution 2.30Å" /> '''STRUCTURE OF PROTOP...) |
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==About this Structure== | ==About this Structure== | ||
| - | 2IVD is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Myxococcus_xanthus Myxococcus xanthus]] with ACJ, FAD, TWN and GOL as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.3.4 1.3.3.4]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2IVD OCA]]. | + | 2IVD is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Myxococcus_xanthus Myxococcus xanthus]] with ACJ, FAD, TWN and GOL as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/Protoporphyrinogen_oxidase Protoporphyrinogen oxidase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.3.4 1.3.3.4]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2IVD OCA]]. |
==Reference== | ==Reference== | ||
Crystal structure of protoporphyrinogen oxidase from Myxococcus xanthus and its complex with the inhibitor acifluorfen., Corradi HR, Corrigall AV, Boix E, Mohan CG, Sturrock ED, Meissner PN, Acharya KR, J Biol Chem. 2006 Dec 15;281(50):38625-33. Epub 2006 Oct 17. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17046834 17046834] | Crystal structure of protoporphyrinogen oxidase from Myxococcus xanthus and its complex with the inhibitor acifluorfen., Corradi HR, Corrigall AV, Boix E, Mohan CG, Sturrock ED, Meissner PN, Acharya KR, J Biol Chem. 2006 Dec 15;281(50):38625-33. Epub 2006 Oct 17. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17046834 17046834] | ||
[[Category: Myxococcus xanthus]] | [[Category: Myxococcus xanthus]] | ||
| + | [[Category: Protoporphyrinogen oxidase]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Acharya, K.R.]] | [[Category: Acharya, K.R.]] | ||
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[[Category: protoporphyrinogen oxidase]] | [[Category: protoporphyrinogen oxidase]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 12:09:22 2007'' |
Revision as of 10:04, 30 October 2007
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STRUCTURE OF PROTOPORPHYRINOGEN OXIDASE FROM MYXOCOCCUS XANTHUS WITH ACIFLUORFEN
Overview
Protoporphyrinogen IX oxidase, a monotopic membrane protein, which, catalyzes the oxidation of protoporphyrinogen IX to protoporphyrin IX in, the heme/chlorophyll biosynthetic pathway, is distributed widely, throughout nature. Here we present the structure of protoporphyrinogen IX, oxidase from Myxococcus xanthus, an enzyme with similar catalytic, properties to human protoporphyrinogen IX oxidase that also binds the, common plant herbicide, acifluorfen. In the native structure, the planar, porphyrinogen substrate is mimicked by a Tween 20 molecule, tracing three, sides of the macrocycle. In contrast, acifluorfen does not mimic the, planarity of the substrate but is accommodated by the shape of the binding, pocket and held in place by electrostatic and aromatic interactions. A, hydrophobic ... [(full description)]
About this Structure
2IVD is a [Single protein] structure of sequence from [Myxococcus xanthus] with ACJ, FAD, TWN and GOL as [ligands]. Active as [Protoporphyrinogen oxidase], with EC number [1.3.3.4]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Crystal structure of protoporphyrinogen oxidase from Myxococcus xanthus and its complex with the inhibitor acifluorfen., Corradi HR, Corrigall AV, Boix E, Mohan CG, Sturrock ED, Meissner PN, Acharya KR, J Biol Chem. 2006 Dec 15;281(50):38625-33. Epub 2006 Oct 17. PMID:17046834
Page seeded by OCA on Tue Oct 30 12:09:22 2007
Categories: Myxococcus xanthus | Protoporphyrinogen oxidase | Single protein | Acharya, K.R. | Boix, E. | Corradi, H.R. | Corrigall, A.V. | Meissner, P.N. | Mohan, C.G. | Sturrock, E.D. | ACJ | FAD | GOL | TWN | Acifluorfen | Chlorophyll biosynthesis | Fad | Flavoprotein | Haem biosynthesis | Heme biosynthesis | Oxidoreductase | Porphyria | Porphyrin biosynthesis
