This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
Plectin
From Proteopedia
Jae-Geun Song (Talk | contribs)
(New page: <Structure load='1sh6' size='500' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' /><!-- Please use the "3D" button above this box to inse...)
Next diff →
Revision as of 13:10, 23 June 2011
|
Plectin, a universal and functionally versatile cytolinker protein, can be divided in three main sections; a central coiled-coil rod domain, N and C-terminal globular region and exhibits a dumbbell like structure (1). C-terminal region is composed of 6 homologous repeating domains, and this region has a role in binding to intermediate filaments such as vimentin and cytokeratin (2). N-terminal globular region contains actin binding domain (ABD) comprising two calponin homology (CH) domains and N-terminal arm, which varies among isoforms (3).
1. Foisner, R., and Wiche, G. (1987) J Mol Biol 198, 515-531
2. Nikolic, B., Mac Nulty, E., Mir, B., and Wiche, G. (1996) J Cell Biol 134, 1455-1467
3. Fuchs, P., Zorer, M., Rezniczek, G. A., Spazierer, D., Oehler, S., Castanon, M. J., Hauptmann, R., and Wiche, G. (1999) Hum Mol Genet 8, 2461-2472
