User:User:Marcia Ivonne Peña Paz
From Proteopedia
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It is a transcription factor from the basic-helix-loop-helix (bHLH)/ PAS protein family. | It is a transcription factor from the basic-helix-loop-helix (bHLH)/ PAS protein family. | ||
| - | It is part of the transcriptional/translational feed back loop of the circadian timing system. It forms an heterodimer with CLOCK and both translocate into the nucleus. | + | It is part of the transcriptional/translational feed back loop of the circadian timing system. It forms an heterodimer with CLOCK or NPAS2 and both translocate into the nucleus. |
The heterodimer binds to E-box promoter elements of target genes. It modulates the expression of the genes ''cry'', ''per'', ''dbp'', ''ror'', ''ppara'', ''namt'', ''ccg'', ''myod'', cki. | The heterodimer binds to E-box promoter elements of target genes. It modulates the expression of the genes ''cry'', ''per'', ''dbp'', ''ror'', ''ppara'', ''namt'', ''ccg'', ''myod'', cki. | ||
Revision as of 14:41, 23 June 2011
BMAL_1
Brain and muscle Arnt like 1. Also known as MOP3
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It is a transcription factor from the basic-helix-loop-helix (bHLH)/ PAS protein family.
It is part of the transcriptional/translational feed back loop of the circadian timing system. It forms an heterodimer with CLOCK or NPAS2 and both translocate into the nucleus. The heterodimer binds to E-box promoter elements of target genes. It modulates the expression of the genes cry, per, dbp, ror, ppara, namt, ccg, myod, cki.
