Group:MUZIC:Calcineurin
From Proteopedia
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| - | <Structure load='1aui' size='500' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' />Calcium-dependent, calmodulin-stimulated protein phosphatase <scene name='User:Ariadna_Rodriguez-Chamorro/Workbench/Calcineurin/Calcium_dependent_calciuneurin/1'>calcineurin</scene> | + | The calcium/calmodulin-dependent phosphatase calcineurin is localized in the nucleus and in the Z-disc of muscle fibers. The <scene name='User:Ariadna_Rodriguez-Chamorro/Workbench/Calcineurin/Calcium_dependent_calciuneurin/1'>calcium/calmodulin-dependent phosphatase calcineurin</scene> is composed by two chains: chain A which is the catalytic subunit and the B chain confers calcium sensitivity. |
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| + | Its chain A bears the interaction sites for | ||
| + | Its activity is controled by calcium signals that lead to remodeling of skeletal and cardiac muscle in response to physiological and pathological stimuli. In addition to several cytoplasmic substrates, calcineurin dephosphorylates | ||
| + | members of the nuclear factor of activated T-cell (NFAT) family | ||
| + | of transcription factors, resulting in their nuclear translocation and | ||
| + | activation of target genes. | ||
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| + | <Structure load='1aui' size='500' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' />Calcium-dependent, calmodulin-stimulated protein phosphatase <scene name='User:Ariadna_Rodriguez-Chamorro/Workbench/Calcineurin/Calcium_dependent_calciuneurin/1'>calcium/calmodulin-dependent phosphatase calcineurin</scene> | ||
Revision as of 16:10, 23 June 2011
The calcium/calmodulin-dependent phosphatase calcineurin is localized in the nucleus and in the Z-disc of muscle fibers. The is composed by two chains: chain A which is the catalytic subunit and the B chain confers calcium sensitivity.
Its chain A bears the interaction sites for
Its activity is controled by calcium signals that lead to remodeling of skeletal and cardiac muscle in response to physiological and pathological stimuli. In addition to several cytoplasmic substrates, calcineurin dephosphorylates
members of the nuclear factor of activated T-cell (NFAT) family
of transcription factors, resulting in their nuclear translocation and
activation of target genes.
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