Group:MUZIC:Calcineurin
From Proteopedia
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[[Image:Calcineurin1.jpg]] | [[Image:Calcineurin1.jpg]] | ||
| - | == Calcineurin | + | == Calcineurin == |
| - | + | Calcineurin is a calcium calmoduline dependent phosphatase present in many different type of cells. This phosphatase has been described to be mainly localized in the cyoplasma where dephosphorylates members of the nuclear factor of activated T-cell (NFAT) family of transcription factors. As a result NFAT is translocated to the nuclei and activates target genes.<ref>PMID: 9143705</ref> | |
== Structure == | == Structure == | ||
<Structure load='1aui' size='300' frame='true' align='right' caption='Insert caption here' scene ='User:Ariadna_Rodriguez-Chamorro/Workbench/Calcineurin/Calcium_dependent_calcineurin/10'/> | <Structure load='1aui' size='300' frame='true' align='right' caption='Insert caption here' scene ='User:Ariadna_Rodriguez-Chamorro/Workbench/Calcineurin/Calcium_dependent_calcineurin/10'/> | ||
| - | The calcium/calmodulin-dependent phosphatase calcineurin is composed by two chains: chain A which is the catalytic subunit and the B chain confers calcium sensitivity. | + | The calcium/calmodulin-dependent phosphatase calcineurin is composed by two chains: chain A, (CnA) which is the catalytic subunit and the B chain (CnB) confers calcium sensitivity. |
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| + | == Calcineurin in the muscle cells == | ||
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| + | This calcium/calmodulin-dependent protein serine/threonine phosphate is localized in the nucleus and in the Z-disc of muscle fibers. Its activity is controled by calcium signals that lead to remodeling of skeletal and cardiac muscle in response to physiological and pathological stimuli. | ||
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| + | == Calcineurin interactions and their physiological role == | ||
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| + | == Further Readings == | ||
==References== | ==References== | ||
<references/> | <references/> | ||
Revision as of 10:13, 24 June 2011
Contents |
Calcineurin
Calcineurin is a calcium calmoduline dependent phosphatase present in many different type of cells. This phosphatase has been described to be mainly localized in the cyoplasma where dephosphorylates members of the nuclear factor of activated T-cell (NFAT) family of transcription factors. As a result NFAT is translocated to the nuclei and activates target genes.[1]
Structure
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The calcium/calmodulin-dependent phosphatase calcineurin is composed by two chains: chain A, (CnA) which is the catalytic subunit and the B chain (CnB) confers calcium sensitivity.
Calcineurin in the muscle cells
This calcium/calmodulin-dependent protein serine/threonine phosphate is localized in the nucleus and in the Z-disc of muscle fibers. Its activity is controled by calcium signals that lead to remodeling of skeletal and cardiac muscle in response to physiological and pathological stimuli.
Calcineurin interactions and their physiological role
Further Readings
References
- ↑ Rao A, Luo C, Hogan PG. Transcription factors of the NFAT family: regulation and function. Annu Rev Immunol. 1997;15:707-47. PMID:9143705 doi:10.1146/annurev.immunol.15.1.707
