Group:MUZIC:ANKRD2

From Proteopedia

proteopedia linkproteopedia link

Revision as of 10:48, 24 June 2011 (edit) Spyros D. Chatziefthimiou (Talk | contribs) ← Previous diff		Revision as of 10:48, 24 June 2011 (edit) (undo) Spyros D. Chatziefthimiou (Talk | contribs) Next diff →
Line 26:		Line 26:
	<references/>		<references/>
-
-	--
-	Spyros D. Chatziefthimiou, Ph.D.
-
-	European Molecular Biology Laboratory
-	Building 25A, c/o DESY
-	Notkestraße 85
-	22603 Hamburg
-	Germany
-
-	Tel: +49 40 89902247
-	Fax: +49 40 89902149
-
-	spchatzi@embl-hamburg.de

---

Revision as of 10:48, 24 June 2011

ANKRD2

Human AKRD2 (ankyrin repeat domain 2) encodes a 37 kDa protein, found in slow muscle fibers. It belongs to the conserved muscle ankyrin repeat protein (MARP) family. It forms a link between the sarcomere and nucleus in skeletal muscle and is involved in striated muscle hypertrophy. AnkrD2 interacts with telethonin and the transcription factors YB-1, PML and p53.^[1]

spinqualitylabelsall models Structure of a designed ankyrin repeat protein (DARPin) with five ankyrin repeat motifs (2QYJ) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

References:

1. ↑ Kojic S, Medeot E, Guccione E, Krmac H, Zara I, Martinelli V, Valle G, Faulkner G. The Ankrd2 protein, a link between the sarcomere and the nucleus in skeletal muscle. J Mol Biol. 2004 May 28;339(2):313-25. PMID:15136035 doi:10.1016/j.jmb.2004.03.071