Virus protease

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	[[3p1g]] – XMRV-PR RNase H domain (mutant)		[[3p1g]] – XMRV-PR RNase H domain (mutant)
-	==Rous sarcoma virus protease==	+	===Rous sarcoma virus protease===
	[[1bai]] – RSVP + polypeptide inhibitor _ Rous sarcoma virus		[[1bai]] – RSVP + polypeptide inhibitor _ Rous sarcoma virus
-	==Human Cytomegalovirus protease==	+	===Human Cytomegalovirus protease===
	[[1cmv]], [[1lay]] – CMVP (mutant) – human herpes virus		[[1cmv]], [[1lay]] – CMVP (mutant) – human herpes virus
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	[[2wpo]] - CMVP (mutant) + inhibitor		[[2wpo]] - CMVP (mutant) + inhibitor
-	==Varicella-Zoster virus protease==	+	===Varicella-Zoster virus protease===
	[[1vzv]] - VZVP (mutant) – human herpes virus		[[1vzv]] - VZVP (mutant) – human herpes virus
-	==Equine infectious anemia virus protease==	+	===Equine infectious anemia virus protease===
	[[2fmb]] – EIAVP (mutant) + inhibitor		[[2fmb]] – EIAVP (mutant) + inhibitor
-	==Hepatitis A virus protease==	+	===Hepatitis A virus protease===
	[[2h9h]] – HAVP residues 1520-1731 (mutant) + polypeptide inhibitor		[[2h9h]] – HAVP residues 1520-1731 (mutant) + polypeptide inhibitor
	[[Category:Topic Page]]		[[Category:Topic Page]]

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Revision as of 07:03, 26 June 2011

Template:STRUCTURE 1odw

Virus proteases include HIV protease, XMRV protease, retropepsin. HIV Protease (HIV-PR) and xenotropic murine leukemia virus protease (XMRV-PR) cleave polyproteins to produce the mature proteins of the virus. Both are aspartyl proteases. The inhibition of HIV-PR results in an uninfectious HIV virion. HIV-1 is found globally while HIV-2, which has lower virulence, is found in West Africa.

3D Structures of Virus proteases

Update June 2011

HIV-1

3ixo - HIV1-PR subtype A
1odx, 2hb2, 2hb4, 2pc0 - HIV1-PR (mutant)
1rpi, 1rq9, 1tw7 - HIV1-PR (drug-resistant mutant)
1odw, 3kf1 - HIV1-PR

HIV-1 complexes

1hsg, 1hsh, 1hsi, 3oxc, 3ekv, 3ekx, 3eky, 3el1, 1ohr - HIV1-PR + antiviral drug
1aid, 1qbr, 1qbs, 1qbt, 1qbu, 3mxe, 3m9f , 3kf0, 3kf1, 3kfn, 3kfp, 3kfr, 3kfs, 2wkz, 2wl0, 3gga, 3ggv, 3ggx, 2uxz, 2uy0, 1zp8, 1xl2, 1xl5, 1zpa, 1yt9, 2a4f , 1upj, 2upj, 7upj, 1hxb, 1hih, 1hvr, 1hef, 1heg, 4phv, 1w5w, 1w5x, 1w5v, 1w5y, 1t7k, 1npa, 1npv, 1npw, 1eby, 1ec0, 1g2k, 1c6x, 1c6y, 1c6z, 1hwr, 2bpv, 2bpw, 2bpx, 2bpy, 2bpz, 1ody, 1hvh, 3tlh, 1hxw - HIV1-PR + inhibitor
2zye - HIV1-PR + inhibitor - neutron
3aid, 1ytg, 1yth, 2nxd, 2nxl, 2nxm, 2fns, 2fnt, 1zj7, 1zlf, 1zpk, 1zsf, 1zsr, 1cpi, 1m0b, 1iiq, 1fqx, 1a30 - HIV1-PR + polypeptide derivative
1sp5 - HIV1-PR + autoproteolytic peptide

HIV-1 (mutant) complexes

3nu3, 3nu4, 3nu5, 3nu6, 3nu9, 3nuj, 3nuo, 2qhc, 2qak, 2pym, 2pyn, 2q63, 2q64, 2fxd, 2fxe, 2fgu, 2fgv, 1sdt, 1sdu, 1sdv, 1d4y, 1d4s - HIV1-PR (mutant) + antiviral drug
2aid, 1hpo, 1tcx, 1gnm, 1gnn, 1gno, 1kzk, 3ok9, 3i8w, 3i7e, 3bxr, 3bxs, 2hc0, 2psu, 2psv, 2fle, 2f3k, 2ien, 2fdd, 2fde, 1t7i, 1t3r, 1mrw, 1mrx, 1msm, 1msn, 1bv9 - HIV1-PR (mutant) + inhibitor
2p3b - HIV1-PR subtype B (mutant) + inhibitor
2p3c - HIV1-PR subtype F (mutant) + inhibitor
1zbg, 1z8c, 2az9, 2azc, 2a1e, 1lzq, 1d4k, 1d4l, 1a8k, 1a94, 1axa - HIV1-PR (mutant) + polypeptide derivative
1ztz - HIV1-PR (mutant) + autoproteolytic polypeptide + metalacarborane

HIV-1 (drug-resistant mutant) complexes

3el4, 3el9, 3em3, 3em4, 3em6, 3ggt, 3ggu, 1t7j, 1rv7, 1n49, 1fb7 - HIV1-PR (drug-resistant mutant) + antiviral drug
1izh, 1izi, 1fb7 - HIV1-PR (drug-resistant mutant) + inhibitor
2p3a - HIV1-PR subtype B (drug-resistant mutant) + inhibitor
2p3d - HIV1-PR subtype F (drug-resistant mutant) + inhibitor

HIV-2

1jld - HIV2-PR
1hii - HIV2-PR + inhibitor
5upj, 6upj, 3upj, 4upj - HIV2-PR (mutant) + inhibitor
1ida, 1idb, 2mip - HIV2-PR + polypeptide derivative

Feline Immunodeficiency Virus-PR

2hah, 4fiv - FIV-PR residues 39-154 (mutant) + inhibitor
5fiv, 6fiv, 1b11 - FIV-PR + inhibitor
2fiv, 3fiv - SIV-PR (mutant) + substrate

Simian Immunodeficiency Virus-PR

2sam - SIV-PR + inhibitor
1az5 - SIV-PR (mutant)

XMRV-PR

3nr6 – XMRV-PR P14
3p1g – XMRV-PR RNase H domain (mutant)

Rous sarcoma virus protease

1bai – RSVP + polypeptide inhibitor _ Rous sarcoma virus

Human Cytomegalovirus protease

1cmv, 1lay – CMVP (mutant) – human herpes virus 1wpo – CMVP 2wpo - CMVP (mutant) + inhibitor

Varicella-Zoster virus protease

1vzv - VZVP (mutant) – human herpes virus

Equine infectious anemia virus protease

2fmb – EIAVP (mutant) + inhibitor

Hepatitis A virus protease

2h9h – HAVP residues 1520-1731 (mutant) + polypeptide inhibitor