1e1n
From Proteopedia
(New page: 200px<br /> <applet load="1e1n" size="450" color="white" frame="true" align="right" spinBox="true" caption="1e1n, resolution 2.4Å" /> '''STRUCTURE OF ADRENOD...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1E1N is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]] with FAD as [[http://en.wikipedia.org/wiki/ligand ligand]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1E1N OCA]]. | + | 1E1N is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]] with FAD as [[http://en.wikipedia.org/wiki/ligand ligand]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1E1N OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: oxidoreductase]] | [[Category: oxidoreductase]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 12:10:33 2007'' |
Revision as of 10:05, 30 October 2007
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STRUCTURE OF ADRENODOXIN REDUCTASE AT 2.4 ANGSTROM IN CRYSTAL FORM A
Overview
Adrenodoxin reductase is a flavoenzyme that shuffles electrons for the, biosynthesis of steroids. Its chain topology belongs to the glutathione, reductase family of disulfide oxidoreductases, all of which bind FAD at, equivalent positions. The three reported structures of adrenodoxin, reductase were ligated with reduced and oxidized NADP and have now, confirmed this equivalence also for the NADP-binding site. Remarkably, the, conformations and relative positions of the prosthetic group FAD and the, cofactor NADP have been conserved during protein evolution despite very, substantial changes in the polypeptide. The ligated enzymes showed small, changes in the domain positions. When compared with the structure of the, NADP-free enzyme, these positions correspond to several states of the, ... [(full description)]
About this Structure
1E1N is a [Single protein] structure of sequence from [Bos taurus] with FAD as [ligand]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Crystal structures of adrenodoxin reductase in complex with NADP+ and NADPH suggesting a mechanism for the electron transfer of an enzyme family., Ziegler GA, Schulz GE, Biochemistry. 2000 Sep 12;39(36):10986-95. PMID:10998235
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