2g9c

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(New page: 200px<br /><applet load="2g9c" size="350" color="white" frame="true" align="right" spinBox="true" caption="2g9c, resolution 1.70&Aring;" /> '''Modified pyrimidines...)
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Revision as of 17:54, 29 January 2008

Image:2g9c.gif

2g9c, resolution 1.70Å

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Modified pyrimidines Specifically bind the purine riboswitch

Overview

The purine riboswitch is a genetic regulatory element found in the 5'-untranslated regions of Gram-positive bacteria that regulates expression of the mRNA specifically in response to either guanine or adenine. We report that the adenine-responsive RNA element is also capable of specifically recognizing pyrimidine compounds bearing modifications at the 6- or 5,6-positions in a fashion similar to that of purine compounds. Using isothermal titration calorimetry and X-ray crystallography, the binding of these compounds is characterized.

About this Structure

2G9C is a Protein complex structure of sequences from [1] with , and as ligands. Full crystallographic information is available from OCA.

Reference

Modified pyrimidines specifically bind the purine riboswitch., Gilbert SD, Mediatore SJ, Batey RT, J Am Chem Soc. 2006 Nov 8;128(44):14214-5. PMID:17076468

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