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Thymidine kinase
From Proteopedia
(New page: {{STRUCTURE_2orv| PDB=2orv | SIZE=300| SCENE= |right| CAPTION=Human thymidine kinase 1 complex with bisubstrate inhibitor adenyl thymidyl tetraphosphate, 2orv }} '''Thymidine kina...) |
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== 3D Structures of thymidine kinase == | == 3D Structures of thymidine kinase == | ||
| + | [[2e2h]] – HsvTK – Herpes simplex virus 1<BR /> | ||
| + | [[3e2i]] – TK – Staphylococcus aureus<BR /> | ||
| + | [[2qpo]] – TmTK – Thermotoga maritima | ||
| + | |||
| + | ===Thymidine kinase complex with reactants or products=== | ||
| + | |||
| + | [[1e2i]] - HsvTK + hydroxypropyladenine<BR /> | ||
| + | [[1e2j]] - HsvTK (mutant) + THM<BR /> | ||
| + | [[1kim]] - HsvTK + THM<BR /> | ||
| + | [[1vtk]] - HsvTK + THMP + ADP<BR /> | ||
| + | [[2vtk]] - HsvTK + THM + ADP<BR /> | ||
| + | [[3vtk]] - HsvTK + substrate analog + ADP<BR /> | ||
| + | [[3f0t]], [[1of1]] – HsvTK residues 45-376 + thymine derivative <BR /> | ||
| + | [[1qhi]], [[1ki3]], [[1ki5]], [[1ki2]], [[1ki4]] - HsvTK + inhibitor<BR /> | ||
| + | [[1e2p]], [[1e2m]], [[1e2n]], [[1e2k]], [[1e2l]], [[1ki6]], [[1ki7]], [[1ki8]] – HsvTK + substrate analog<BR /> | ||
| + | [[1osn]] – TK + inhibitor + ADP - Human Herpes virus 3<BR /> | ||
| + | [[1p6x]] – EhvTK + THM – Equine Herpes virus 4<BR /> | ||
| + | [[1p72]] - EhvTK + THM + ADP<BR /> | ||
| + | [[2qqe]] – TmTK + THM<BR /> | ||
| + | [[2qq0]]– TmTK + THM + ADP + THMP + ANP<BR /> | ||
| + | [[2b8t]] - TK + THM – Ureaplasma parvum<BR /> | ||
| + | [[2j9r]] – TK + THM – Bacillus anthracis<BR /> | ||
| + | [[1xx6]] – TK + ADP – Clostridium acetobutylicum | ||
| + | |||
| + | ===Thymidine kinase complex with feed-back inhibitor=== | ||
| + | |||
| + | [[2j87]] – TK + TTP – Vaccinia virus<BR /> | ||
| + | [[2uz3]] – TK (mutant) + TTP – Ureaplasma urealyticum<BR /> | ||
| + | [[2ja1]] – TK + TTP – Bacillus cereus | ||
| + | |||
| + | ===Thymidine kinase complex with bisubstrate inhibitor=== | ||
| + | |||
| + | [[1p7c]] – HsvTK + TP5A<BR /> | ||
| + | [[1p73]] - EhvTK + TP4A<BR /> | ||
| + | [[1p75]] - EhvTK + TP5A<BR /> | ||
| + | [[2orw]] – TmTK + TP4A<BR /> | ||
| + | |||
| + | ===Thymidine kinase 1=== | ||
| + | |||
| + | [[1xbt]] - hTK1 residues 1-193 – human<BR /> | ||
| + | [[2wvj]] – hTK1 residues 1-193 (mutant) + TTP<BR /> | ||
| + | [[2orv]] – hTK1 (mutant) + TP4A<BR /> | ||
| + | |||
| + | ===Thymidine kinase 2=== | ||
| + | |||
| + | [[1w4r]] – hTK2 + TTP | ||
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[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 08:31, 30 June 2011
Thymidine kinase (TK) catalyzes the conversion of deoxythymidine (THM) to deoxythymidine 5’-phosphate (THMP) with the coversion of ATP to ADP. TK has an important role in the synthesis of DNA. It is required for the action of many antiviral drugs. Higher organisms have 2 isozymes. TK1 is cell cycle-dependent while TK2 is found in the mitochondria and is cell cycle-independent. TK undergoes feed-back regulation by thymidine triphosphate (TTP). Adenosyl-thymidyl-tetraphosphate (TP4A) is a bisubstrate inhibitor of TK.
Contents |
3D Structures of thymidine kinase
2e2h – HsvTK – Herpes simplex virus 1
3e2i – TK – Staphylococcus aureus
2qpo – TmTK – Thermotoga maritima
Thymidine kinase complex with reactants or products
1e2i - HsvTK + hydroxypropyladenine
1e2j - HsvTK (mutant) + THM
1kim - HsvTK + THM
1vtk - HsvTK + THMP + ADP
2vtk - HsvTK + THM + ADP
3vtk - HsvTK + substrate analog + ADP
3f0t, 1of1 – HsvTK residues 45-376 + thymine derivative
1qhi, 1ki3, 1ki5, 1ki2, 1ki4 - HsvTK + inhibitor
1e2p, 1e2m, 1e2n, 1e2k, 1e2l, 1ki6, 1ki7, 1ki8 – HsvTK + substrate analog
1osn – TK + inhibitor + ADP - Human Herpes virus 3
1p6x – EhvTK + THM – Equine Herpes virus 4
1p72 - EhvTK + THM + ADP
2qqe – TmTK + THM
2qq0– TmTK + THM + ADP + THMP + ANP
2b8t - TK + THM – Ureaplasma parvum
2j9r – TK + THM – Bacillus anthracis
1xx6 – TK + ADP – Clostridium acetobutylicum
Thymidine kinase complex with feed-back inhibitor
2j87 – TK + TTP – Vaccinia virus
2uz3 – TK (mutant) + TTP – Ureaplasma urealyticum
2ja1 – TK + TTP – Bacillus cereus
Thymidine kinase complex with bisubstrate inhibitor
1p7c – HsvTK + TP5A
1p73 - EhvTK + TP4A
1p75 - EhvTK + TP5A
2orw – TmTK + TP4A
Thymidine kinase 1
1xbt - hTK1 residues 1-193 – human
2wvj – hTK1 residues 1-193 (mutant) + TTP
2orv – hTK1 (mutant) + TP4A
Thymidine kinase 2
1w4r – hTK2 + TTP
