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Group:MUZIC:Nebulin
From Proteopedia
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==Introduction== | ==Introduction== | ||
| - | <StructureSection load='1ark' size='500' side='right' caption='NMR structure of the SH3 domain of Nebulin' scene='User:Marie-Cecile_Pelissier/Workbench/Nebulin/Barrel/2'>Nebulin (UniProt ID P20929 [http://www.uniprot.org/uniprot/P20929]) is a very large filamentous protein (600-900 kDa) tightly associated to the thin filament of the muscle sarcomere throughout its length. Nebulin is mostly found within the sarcomeres of skeletal muscles but was also identified at a low level in cardiac muscle cells. Indeed, the sarcomeres of cardiac muscles predominantly contain a Nebulin-like protein called Nebulette which is a "short version" of Nebulin, highly similar to its C-terminal part. | + | <StructureSection load='1ark' size='500' side='right' caption='NMR structure of the SH3 domain of Nebulin' scene='User:Marie-Cecile_Pelissier/Workbench/Nebulin/Barrel/2'>Nebulin (UniProt ID P20929 [http://www.uniprot.org/uniprot/P20929]) is a very large filamentous protein (600-900 kDa) tightly associated to the thin filament of the muscle sarcomere throughout its length. Nebulin is mostly found within the sarcomeres of skeletal muscles but was also identified at a low level in cardiac muscle cells. Indeed, the sarcomeres of cardiac muscles predominantly contain a Nebulin-like protein called Nebulette (http://www.uniprot.org/uniprot/O76041) which is a "short version" of Nebulin, highly similar to its C-terminal part. |
It is involved in the structural integrity of the sarcomeres and is linked to many signalling pathways crucial for the maintenance of the sarcomere.</StructureSection> | It is involved in the structural integrity of the sarcomeres and is linked to many signalling pathways crucial for the maintenance of the sarcomere.</StructureSection> | ||
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Revision as of 12:37, 1 July 2011
Contents |
Introduction
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Function
Domains and interactions
Glutamic rich region
Nebulin modules
Serine rich region
SH3 domain
The Nebulin SH3 domain adopts a ß-Barrel .
Refrences
Interactions
References
Proteopedia Page Contributors and Editors (what is this?)
Marie-Cecile Pelissier, Michal Harel, Jaime Prilusky, Nikos Pinotsis
