2gku
From Proteopedia
OCA (Talk | contribs)
(New page: 200px<br /><applet load="2gku" size="350" color="white" frame="true" align="right" spinBox="true" caption="2gku" /> '''Monomeric human telomere DNA tetraplex with ...)
Next diff →
Revision as of 18:02, 29 January 2008
|
Monomeric human telomere DNA tetraplex with 3+1 strand fold topology, two edgewise loops and double-chain reversal loop, NMR, 12 structures
Overview
We present the intramolecular G-quadruplex structure of human telomeric, DNA in physiologically relevant K(+) solution. This G-quadruplex, whose (3, + 1) topology differs from folds reported previously in Na(+) solution and, in a K(+)-containing crystal, involves the following: one anti.syn.syn.syn, and two syn.anti.anti.anti G-tetrads; one double-chain reversal and two, edgewise loops; three G-tracts oriented in one direction and the fourth in, the opposite direction. The topological characteristics of this (3 + 1), G-quadruplex scaffold should provide a unique platform for structure-based, anticancer drug design targeted to human telomeric DNA.
About this Structure
2GKU is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structure of the human telomere in K+ solution: an intramolecular (3 + 1) G-quadruplex scaffold., Luu KN, Phan AT, Kuryavyi V, Lacroix L, Patel DJ, J Am Chem Soc. 2006 Aug 2;128(30):9963-70. PMID:16866556
Page seeded by OCA on Tue Jan 29 20:02:07 2008
