Group:MUZIC:Plectin
From Proteopedia
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== Overall structure == | == Overall structure == | ||
| - | Plectin can be divided in three main sections; a central coiled-coil rod domain, N and C-terminal globular region and exhibits a dumbbell like structure. C-terminal region is composed of 6 homologous repeating domains, and this region has a role in binding to intermediate filaments such as vimentin and cytokeratin <ref>PMID:3430617</ref>. N-terminal globular region contains actin binding domain (ABD) comprising two calponin homology (<scene name='User:Jae-Geun_Song/Workbench/plectin/Plecin_actin_binding_domain/3'>CH1 and CH2</scene>) and <scene name='User:Jae-Geun_Song/Workbench/plectin/Plectin_plakin_domain/1'>plakin domain</scene>. | + | Plectin can be divided in three main sections; a central coiled-coil rod domain, N and C-terminal globular region and exhibits a dumbbell like structure. C-terminal region is composed of 6 homologous repeating domains, and this region has a role in binding to intermediate filaments such as vimentin and cytokeratin <ref>PMID:3430617</ref>. N-terminal globular region contains actin binding domain (ABD) comprising two calponin homology (<scene name='User:Jae-Geun_Song/Workbench/plectin/Plecin_actin_binding_domain/3'>CH1 and CH2</scene>) and <scene name='User:Jae-Geun_Song/Workbench/plectin/Plectin_plakin_domain/1'>plakin domain</scene>.[[Image:plectin_structure.jpg]] |
== References == | == References == | ||
Revision as of 12:05, 4 July 2011
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Introduction
Plectin is a multidomain protein with large size (>500kDa) and versatile binding properties, which abundantly expressed in a wide variety of mammalian tissues and cell types, combined with different binding partners. [1].
Overall structure
Plectin can be divided in three main sections; a central coiled-coil rod domain, N and C-terminal globular region and exhibits a dumbbell like structure. C-terminal region is composed of 6 homologous repeating domains, and this region has a role in binding to intermediate filaments such as vimentin and cytokeratin [2]. N-terminal globular region contains actin binding domain (ABD) comprising two calponin homology () and .Image:Plectin structure.jpg
References
- ↑ Fuchs P, Zorer M, Rezniczek GA, Spazierer D, Oehler S, Castanon MJ, Hauptmann R, Wiche G. Unusual 5' transcript complexity of plectin isoforms: novel tissue-specific exons modulate actin binding activity. Hum Mol Genet. 1999 Dec;8(13):2461-72. PMID:10556294
- ↑ Foisner R, Wiche G. Structure and hydrodynamic properties of plectin molecules. J Mol Biol. 1987 Dec 5;198(3):515-31. PMID:3430617
Proteopedia Page Contributors and Editors (what is this?)
Jae-Geun Song, Alexander Berchansky, Nikos Pinotsis, Jaime Prilusky, Michal Harel
