Group:MUZIC:Zyxin
From Proteopedia
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==ZYXIN== | ==ZYXIN== | ||
| - | Zyxin is a protein of the zyxin/ajuba family, encode by the gene [http://www.uniprot.org/uniprot/Q15942],that codes for a protein of 84 kDa that contains 3 LIM zinc-binding domains. | + | Zyxin is a protein of the zyxin/ajuba family, encode by the gene ZYX [http://www.uniprot.org/uniprot/Q15942],that codes for a protein of 84 kDa that contains 3 LIM zinc-binding domains. |
==Function== | ==Function== | ||
Revision as of 12:43, 4 July 2011
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Contents |
ZYXIN
Zyxin is a protein of the zyxin/ajuba family, encode by the gene ZYX [1],that codes for a protein of 84 kDa that contains 3 LIM zinc-binding domains.
Function
Zyxin is an adhesion plaque protein, there by associates with the actin cytoskeleton near the adhesion plaques. Enters the nucleus in the presence of HESX1. Ref.1 Ref.2 It is postulate, that Zyxin may be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression by similarity.
Interactions
Performing yeast two-hybrid analysis system, Yu and Luo found that myopodin interacts with zyxin both in vitro and in vivo and that this interaction leads to slower migration of prostate cancer cells and reduced invasiveness (Yu YP, Luo JH, 2006). Zyxin interacts with HPV type 6 protein E6. Interacts, via the Pro-rich regions, with the EVH1 domains of ENAH, EVL and VASP. Interacts with the first LIM domain of TES. Ref.3 Ref.4 Ref.5 Ref.6 Subcellular location... Cell junction and focal adhesion...
