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Group:MUZIC:XIN
From Proteopedia
(New page: '''Xin actin-binding repeat-containing protein 1''' (Alternative name: Cardiomyopathy-associated protein 1) is coded by the gene (Synonyms:CMYA1, XIN) synohas an actin-binding domain (ABD...) |
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| - | '''Xin actin-binding repeat-containing protein 1''' (Alternative name: Cardiomyopathy-associated protein 1) is coded by the gene (Synonyms:CMYA1, XIN) | + | '''Xin actin-binding repeat-containing protein 1''' (Alternative name: Cardiomyopathy-associated protein 1) is coded by the gene (Synonyms:CMYA1, XIN) and has an actin-binding domain (ABD). It crosslinks actin filaments and participates in anchoring of membrane proteins. |
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| - | == | + | == Sequence Annotation == |
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[[2wfn]], [[3hop]], [[3hor]] – hFLNA ABD<br /> | [[2wfn]], [[3hop]], [[3hor]] – hFLNA ABD<br /> | ||
[[3hoc]] – hFLNA ABD (mutant)<br /> | [[3hoc]] – hFLNA ABD (mutant)<br /> | ||
| - | [[2aav]] - hFLNA domain 17 – NMR<br /> | ||
| - | [[2bp3]] - hFLNA domain 17+GPIB peptide<br /> | ||
| - | [[2k7p]] – hFLNA domains 16-17<br /> | ||
| - | [[2k7q]] - hFLNA domains 18-19<br /> | ||
| - | [[2j3s]] - hFLNA domains 19-21<br /> | ||
| - | [[2w0p]] - hFLNA domain 21+migfilin peptide<br /> | ||
| - | [[2jf1]], [[2brq]] - hFLNA domain 21+integrin peptide<br /> | ||
| - | [[2k3t]] - hFLNA domain 23 – NMR<br /> | ||
| - | [[3cnk]] - hFLNA DD<br /> | ||
| - | == | + | == Function == |
| + | |||
| + | == Interactions with other proteins == | ||
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| - | == Filamin C == | ||
| - | [[2k9u]] – hFLNC+migfilin peptide<br /> | ||
| - | [[2d7m]], [[2d7n]], [[2d7o]], [[2d7p]] - hFLNC domains 14, 16, 17, 22 - NMR<br /> | ||
| - | [[2nqc]] - hFLNC domain 21<br /> | ||
| - | [[2d7q]] - hFLNC domain 23 – NMR<br /> | ||
| - | [[1v05]] - hFLNC DD<br /> | ||
| - | + | == Clinical significance == | |
| - | == | + | |
[[1wlh]], [[1qfh]] – FLN rod domain – ''Dictyostelium discoideum''<br /> | [[1wlh]], [[1qfh]] – FLN rod domain – ''Dictyostelium discoideum''<br /> | ||
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==References== | ==References== | ||
Revision as of 07:50, 5 July 2011
Xin actin-binding repeat-containing protein 1 (Alternative name: Cardiomyopathy-associated protein 1) is coded by the gene (Synonyms:CMYA1, XIN) and has an actin-binding domain (ABD). It crosslinks actin filaments and participates in anchoring of membrane proteins.
Contents |
Sequence Annotation
3isw – hFLNA repeat 21+CFTR peptide – human
2wfn, 3hop, 3hor – hFLNA ABD
3hoc – hFLNA ABD (mutant)
Function
Interactions with other proteins
2wa5, 3fer, 2eea - hFLNB ABD
2wa6, 2wa7 - hFLNB ABD (mutant)
2di9, 2dia, 2dib, 2dic, 2dj4, 2e9j, 2dmb, 2ee9, 2ee7, 2dmc, 2di8, 2dlg, 2e9i, 2ee6, 2eeb, 2eec, 2eed - hFLNB domains 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 20, 21, 22, 23, 24 – NMR
Clinical significance
1wlh, 1qfh – FLN rod domain – Dictyostelium discoideum
References
http://www.uniprot.org/uniprot/Q702N8
