2c3f
From Proteopedia
(New page: 200px<br /> <applet load="2c3f" size="450" color="white" frame="true" align="right" spinBox="true" caption="2c3f, resolution 1.81Å" /> '''THE STRUCTURE OF A ...) |
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==About this Structure== | ==About this Structure== | ||
| - | 2C3F is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Streptococcus_pyogenes Streptococcus pyogenes]] with NA as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.2.1 4.2.2.1]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2C3F OCA]]. | + | 2C3F is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Streptococcus_pyogenes Streptococcus pyogenes]] with NA as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/Hyaluronate_lyase Hyaluronate lyase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.2.1 4.2.2.1]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2C3F OCA]]. |
==Reference== | ==Reference== | ||
Structure of a group A streptococcal phage-encoded virulence factor reveals a catalytically active triple-stranded beta-helix., Smith NL, Taylor EJ, Lindsay AM, Charnock SJ, Turkenburg JP, Dodson EJ, Davies GJ, Black GW, Proc Natl Acad Sci U S A. 2005 Dec 6;102(49):17652-7. Epub 2005 Nov 28. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16314578 16314578] | Structure of a group A streptococcal phage-encoded virulence factor reveals a catalytically active triple-stranded beta-helix., Smith NL, Taylor EJ, Lindsay AM, Charnock SJ, Turkenburg JP, Dodson EJ, Davies GJ, Black GW, Proc Natl Acad Sci U S A. 2005 Dec 6;102(49):17652-7. Epub 2005 Nov 28. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16314578 16314578] | ||
| + | [[Category: Hyaluronate lyase]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Streptococcus pyogenes]] | [[Category: Streptococcus pyogenes]] | ||
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[[Category: triple-stranded beta-helix]] | [[Category: triple-stranded beta-helix]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 12:12:37 2007'' |
Revision as of 10:07, 30 October 2007
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THE STRUCTURE OF A GROUP A STREPTOCOCCAL PHAGE-ENCODED TAIL-FIBRE SHOWING HYALURONAN LYASE ACTIVITY.
Overview
Streptococcus pyogenes (group A Streptococcus) causes severe invasive, infections including scarlet fever, pharyngitis (streptococcal sore, throat), skin infections, necrotizing fasciitis (flesh-eating disease), septicemia, erysipelas, cellulitis, acute rheumatic fever, and toxic, shock. The conversion from nonpathogenic to toxigenic strains of S., pyogenes is frequently mediated by bacteriophage infection. One of the key, bacteriophage-encoded virulence factors is a putative "hyaluronidase,", HylP1, a phage tail-fiber protein responsible for the digestion of the S., pyogenes hyaluronan capsule during phage infection. Here we demonstrate, that HylP1 is a hyaluronate lyase. The 3D structure, at 1.8-angstroms, resolution, reveals an unusual triple-stranded beta-helical structure and, ... [(full description)]
About this Structure
2C3F is a [Single protein] structure of sequence from [Streptococcus pyogenes] with NA as [ligand]. Active as [Hyaluronate lyase], with EC number [4.2.2.1]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Structure of a group A streptococcal phage-encoded virulence factor reveals a catalytically active triple-stranded beta-helix., Smith NL, Taylor EJ, Lindsay AM, Charnock SJ, Turkenburg JP, Dodson EJ, Davies GJ, Black GW, Proc Natl Acad Sci U S A. 2005 Dec 6;102(49):17652-7. Epub 2005 Nov 28. PMID:16314578
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