Phosphotransferase
From Proteopedia
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| - | ==3D structures of | + | ==3D structures of phosphotransferase== |
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| + | [[3our]] – PT IIA + pyruvate decarboxylase – ''Vibrio vulnificus''<BR /> | ||
| + | [[2l5h]], [[2kx9]] - EcPT I]] - ''Escherichia coli'' – NMR<BR /> | ||
| + | [[2xdf]] - EcPT I+ phosphocarrier protein HPR – NMR<BR /> | ||
| + | [[3oxp]] – PT II – ''Yersinia pestis''<BR /> | ||
| + | [[3ci6]] – PT GAF domain – ''Acinetobacter''<BR /> | ||
| + | [[2ooc]] – PT histidine – ''Caulobacter crescentus''<BR /> | ||
| + | [[3ipj]] – PT IIABC – ''Clostridium difficile''<BR /> | ||
| + | [[2f9h]] - PT IIA – ''Enterococcus faecalis''<BR /> | ||
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| + | ===Aminoglycoside phosphotransferase=== | ||
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| + | [[3ovc]] - EcAGPT IA<BR /> | ||
| + | [[3r6z]] - EcAGPT IB<BR /> | ||
| + | [[3q2m]], [[3i1a]] – LpAGPT IA – ''Legionella pneumophila''<BR /> | ||
| + | [[1nd4]] – KpAGPT IIA – ''Klebsiella pneumoniae''<BR /> | ||
| + | [[1qhn]] – SvAGPT – Streptomyces venezuelae<BR /> | ||
| + | [[3sgc]], [[3r7z]], [[3n4t]], [[3n4u]], [[3n4v]] - EncAGPT ID – ''Enterococcus casseliflavus''<BR /> | ||
| + | [[1j7i]] - AGPT IIIA – ''Enterococcus faecalis'' | ||
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| + | ===Aminoglycoside phosphotransferase complex with nucleotide=== | ||
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| + | [[3r70]] - EcAGPT IB + ADP<BR /> | ||
| + | [[3r78]] - EcAGPT IB + ATP<BR /> | ||
| + | [[1qhx]] - SvAGPT + ATP<BR /> | ||
| + | [[3i0q]] - LpAGPT IA + AMP<BR /> | ||
| + | [[1j7l]] - AGPT IIIA + ADP – ''Enterococcus faecalis''<BR /> | ||
| + | [[1j7u]] - AGPT IIIA + AMP-PNP – ''Enterococcus faecalis'' | ||
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| + | ===Aminoglycoside phosphotransferase complex with antibiotic<br />=== | ||
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| + | [[3hav]], [[3ham]] - EfAGPT + ATP + antibiotic – ''Enterococcus faecium''<BR /> | ||
| + | [[3h8p]] - EfAGPT + AMP-PNP + antibiotic<br /> | ||
| + | [[2b0q]], [[1l8t]] - EfAGPT IIIA + ADP + antibiotic<br /> | ||
| + | [[3r80]], [[3r81]] - EcAGPT ID + antibiotic<br /> | ||
| + | [[1grq]], [[1grr]], [[1qhs]] - SvAGPT + antibiotic<br /> | ||
| + | [[1qhy]] - SvAGPT + ATPγ + antibiotic<br /> | ||
| + | [[3sg8]], [[3sg9]] - EncAGPT ID + antibiotic<br /> | ||
| + | [[3i0o]] - LpAGPT IA + ADP + antibiotic<br /> | ||
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| + | ===Aminoglycoside phosphotransferase complex with inhibitor=== | ||
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| + | [[3q2j]] – AGPT IIIA + inhibitor – ''Enterococcus faecalis''<BR /> | ||
| + | [[2bkk]] - EfAGPT IIIA + inhibitor | ||
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| + | ===Phosphoenolpyruvate-protein phosphotransferase=== | ||
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| + | [[2xz7]] – TtPEP PEP-binding domain + phosphoenolpyruvate – ''Thermoanaerobacter tengcongensis''<BR /> | ||
| + | [[2xz9]] - TtPEP PEP-binding domain + pyruvate<BR /> | ||
| + | [[3nbm]] – PEP lactose-specific IIBC – ''Streptococcus pneumoniae''<BR /> | ||
| + | [[2l2q]] - PEP cellbiose-specific IIB – ''Borrelia burgdorferi'' – NMR<BR /> | ||
| + | [[3k1s]] - PEP cellbiose-specific IIA – ''Bacillus anthracis''<BR /> | ||
| + | [[2kyr]] – EcPEP fructose-specific IIB<BR /> | ||
| + | [[2r4q]] - BsPEP fructose-specific IIABC – ''Bacillus subtilis''<BR /> | ||
| + | [[2r48]] - BsPEP fructose-specific IIB<BR /> | ||
| + | [[1vsq]], [[2jzh]], [[2jzn]], [[2jzo]] - EcPEP mannose-specific IIA - NMR<BR /> | ||
| + | [[3bp3]] - EcPEP glucose-specific IIB<BR /> | ||
| + | [[1o53]] - EcPEP glucose-specific IIA N terminal – NMR<BR /> | ||
| + | [[1ggr]] - EcPEP glucose-specific IIA + phosphocarrier protein HPR – NMR<BR /> | ||
| + | [[3bp8]] - EcPEP glucose-specific IIB + NAGC-like transcriptional regulator<BR /> | ||
| + | [[3eye]] - EcPEP acetylgalactosamine-specific IIB<BR /> | ||
| + | [[2oq3]], [[1vrv]] - EcPEP mannitol-specific IIA<BR /> | ||
| + | [[1vkr]] - EcPEP mannitol-specific IIABC – NMR<BR /> | ||
| + | [[1j6t]] - EcPEP mannitol-specific IIABC + phosphocarrier protein HPR – NMR<BR /> | ||
| + | [[2few]] - EcPEP mannitol-specific IIA (mutant) <BR /> | ||
| + | [[1wcr]] - EcPEP diacetylchitobiose-specific IIA (mutant) – NMR<BR /> | ||
| + | [[1h9c]] - EcPEP diacetylchitobiose-specific IIB – NMR<BR /> | ||
| + | [[3ipr]] – EfPEP gluconate-specific IIA<BR /> | ||
| + | [[3bed]] - EfPEP mannose-specific IIA<BR /> | ||
| + | [[1nrz]] - KpPEP sorbose-specific IIB | ||
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Revision as of 11:42, 10 July 2011
Template:STRUCTURE 3q2m
Phosphotransferase (PT) are enzymes which catalyze phosphorylation reactions. The acceptor group can be alcohol, carboxy, nitrogenous, phosphate or a pair ofd groups. Aminoglycoside PT (AGPT) inactivate aminoglycoside antibiotics by phosphorylation. The phosphoenolpyruvate-protein PT (PEP) catalyzes the phosphorylation of protein histidine residues.
3D structures of phosphotransferase
3our – PT IIA + pyruvate decarboxylase – Vibrio vulnificus
2l5h, 2kx9 - EcPT I]] - Escherichia coli – NMR
2xdf - EcPT I+ phosphocarrier protein HPR – NMR
3oxp – PT II – Yersinia pestis
3ci6 – PT GAF domain – Acinetobacter
2ooc – PT histidine – Caulobacter crescentus
3ipj – PT IIABC – Clostridium difficile
2f9h - PT IIA – Enterococcus faecalis
Aminoglycoside phosphotransferase
3ovc - EcAGPT IA
3r6z - EcAGPT IB
3q2m, 3i1a – LpAGPT IA – Legionella pneumophila
1nd4 – KpAGPT IIA – Klebsiella pneumoniae
1qhn – SvAGPT – Streptomyces venezuelae
3sgc, 3r7z, 3n4t, 3n4u, 3n4v - EncAGPT ID – Enterococcus casseliflavus
1j7i - AGPT IIIA – Enterococcus faecalis
Aminoglycoside phosphotransferase complex with nucleotide
3r70 - EcAGPT IB + ADP
3r78 - EcAGPT IB + ATP
1qhx - SvAGPT + ATP
3i0q - LpAGPT IA + AMP
1j7l - AGPT IIIA + ADP – Enterococcus faecalis
1j7u - AGPT IIIA + AMP-PNP – Enterococcus faecalis
Aminoglycoside phosphotransferase complex with antibiotic
3hav, 3ham - EfAGPT + ATP + antibiotic – Enterococcus faecium
3h8p - EfAGPT + AMP-PNP + antibiotic
2b0q, 1l8t - EfAGPT IIIA + ADP + antibiotic
3r80, 3r81 - EcAGPT ID + antibiotic
1grq, 1grr, 1qhs - SvAGPT + antibiotic
1qhy - SvAGPT + ATPγ + antibiotic
3sg8, 3sg9 - EncAGPT ID + antibiotic
3i0o - LpAGPT IA + ADP + antibiotic
Aminoglycoside phosphotransferase complex with inhibitor
3q2j – AGPT IIIA + inhibitor – Enterococcus faecalis
2bkk - EfAGPT IIIA + inhibitor
Phosphoenolpyruvate-protein phosphotransferase
2xz7 – TtPEP PEP-binding domain + phosphoenolpyruvate – Thermoanaerobacter tengcongensis
2xz9 - TtPEP PEP-binding domain + pyruvate
3nbm – PEP lactose-specific IIBC – Streptococcus pneumoniae
2l2q - PEP cellbiose-specific IIB – Borrelia burgdorferi – NMR
3k1s - PEP cellbiose-specific IIA – Bacillus anthracis
2kyr – EcPEP fructose-specific IIB
2r4q - BsPEP fructose-specific IIABC – Bacillus subtilis
2r48 - BsPEP fructose-specific IIB
1vsq, 2jzh, 2jzn, 2jzo - EcPEP mannose-specific IIA - NMR
3bp3 - EcPEP glucose-specific IIB
1o53 - EcPEP glucose-specific IIA N terminal – NMR
1ggr - EcPEP glucose-specific IIA + phosphocarrier protein HPR – NMR
3bp8 - EcPEP glucose-specific IIB + NAGC-like transcriptional regulator
3eye - EcPEP acetylgalactosamine-specific IIB
2oq3, 1vrv - EcPEP mannitol-specific IIA
1vkr - EcPEP mannitol-specific IIABC – NMR
1j6t - EcPEP mannitol-specific IIABC + phosphocarrier protein HPR – NMR
2few - EcPEP mannitol-specific IIA (mutant)
1wcr - EcPEP diacetylchitobiose-specific IIA (mutant) – NMR
1h9c - EcPEP diacetylchitobiose-specific IIB – NMR
3ipr – EfPEP gluconate-specific IIA
3bed - EfPEP mannose-specific IIA
1nrz - KpPEP sorbose-specific IIB
