Group:MUZIC:XIN
From Proteopedia
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== Interactions with other proteins/Function Function == | == Interactions with other proteins/Function Function == | ||
| - | Xin and Mena/VASP colocalize with filamin c in [intercalated discs][http://en.wikipedia.org/wiki/Intercalated_disc](ICD, structure at the end of the myocytes that transduce force from the myofibrils via the cell membranes to the extracelluar matrix and neighboring cells) | + | Xin and Mena/VASP colocalize with filamin c in [intercalated discs][http://en.wikipedia.org/wiki/Intercalated_disc](ICD, structure at the end of the myocytes that transduce force from the myofibrils via the cell membranes to the extracelluar matrix and neighboring cells) in the adult heart <ref>PMID:19773341</ref>. |
Xin directly binds the EVH1 domain proteins Mena and VASP <ref name="pmid16631741">. | Xin directly binds the EVH1 domain proteins Mena and VASP <ref name="pmid16631741">. | ||
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| - | hhhh [ aaaa http://en.wikipedia.org/wiki/Intercalated_disc] | ||
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| - | == Clinical significance == | ||
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| - | [[1wlh]], [[1qfh]] – FLN rod domain – ''Dictyostelium discoideum''<br /> | ||
== References == | == References == | ||
Revision as of 23:57, 11 July 2011
Xin actin-binding repeat-containing protein 1 (Alternative name: Cardiomyopathy-associated protein 1) is coded by the gene (Synonyms:CMYA1, XIN) and has an actin-binding domain (ABD). It crosslinks actin filaments and participates in anchoring of membrane proteins. Intraexogic splicing leads to a least three different isoforms.
Sequence Annotation
Interactions with other proteins/Function Function
Xin and Mena/VASP colocalize with filamin c in [intercalated discs][1](ICD, structure at the end of the myocytes that transduce force from the myofibrils via the cell membranes to the extracelluar matrix and neighboring cells) in the adult heart [1].
Xin directly binds the EVH1 domain proteins Mena and VASP [2]
