Group:MUZIC:XIN
From Proteopedia
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== Interactions with other proteins/ Function == | == Interactions with other proteins/ Function == | ||
| - | Xin and Mena/VASP colocalize with filamin c in | + | Xin and Mena/VASP colocalize with filamin c in [http://en.wikipedia.org/wiki/Intercalated_disc intercalated discs ](ICD, structure at the end of the myocytes that transduce force from the myofibrils via the cell membranes to the extracelluar matrix and neighboring cells) in the adult heart <ref>PMID:19773341</ref>. |
Xin directly binds the EVH1 domain proteins Mena and VASP <ref name="pmid16631741">. | Xin directly binds the EVH1 domain proteins Mena and VASP <ref name="pmid16631741">. | ||
Revision as of 00:18, 12 July 2011
Xin actin-binding repeat-containing protein 1 (Alternative name: Cardiomyopathy-associated protein 1) is coded by the gene (Synonyms:CMYA1, XIN) and has an actin-binding domain (ABD). It crosslinks actin filaments and participates in anchoring of membrane proteins. Intraexogic splicing leads to a least three different isoforms.
Sequence Annotation
Interactions with other proteins/ Function
Xin and Mena/VASP colocalize with filamin c in intercalated discs (ICD, structure at the end of the myocytes that transduce force from the myofibrils via the cell membranes to the extracelluar matrix and neighboring cells) in the adult heart [1].
Xin directly binds the EVH1 domain proteins Mena and VASP [2]
