Group:MUZIC:CARP
From Proteopedia
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'''Introduction''' | '''Introduction''' | ||
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CARDIAC ANKYRIN REPEAT PROTEIN; '''CARP'''belongs to the conserved muscle ankyrin repeat protein (MARP) family, Also known as '''Ankrd1'''.MARP family consist of two more homologous members Ankyrin repeat domain containing protein 2 (Ankrd2) and Diabetes related ankyrin repeat protein DARP. | CARDIAC ANKYRIN REPEAT PROTEIN; '''CARP'''belongs to the conserved muscle ankyrin repeat protein (MARP) family, Also known as '''Ankrd1'''.MARP family consist of two more homologous members Ankyrin repeat domain containing protein 2 (Ankrd2) and Diabetes related ankyrin repeat protein DARP. | ||
{{STRUCTURE_1n0r| PDB=1n11}} | {{STRUCTURE_1n0r| PDB=1n11}} | ||
== Structure == | == Structure == | ||
| - | full-length cDNA encoding ANKRD1 contains a nuclear localization signal, 4 tandem ankyrin-like repeats, multiple phosphorylation sites, and a PEST-rich region, which is typically found in rapidly degraded proteins.'''<ref>pmid 7730328 </ref> | + | Using the N2A region of titin as bait in a yeast 2-hybrid screen of a skeletal muscle cDNA library cloned ANKRD1, which they called CARP. '''<ref>pmid 14583192 </ref> full-length cDNA encoding ANKRD1 contains a nuclear localization signal, 4 tandem ankyrin-like repeats, multiple phosphorylation sites, and a PEST-rich region, which is typically found in rapidly degraded proteins.'''<ref>pmid 7730328 </ref> |
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| + | == Gene Function == | ||
Revision as of 09:48, 19 July 2011
Introduction
CARDIAC ANKYRIN REPEAT PROTEIN; CARPbelongs to the conserved muscle ankyrin repeat protein (MARP) family, Also known as Ankrd1.MARP family consist of two more homologous members Ankyrin repeat domain containing protein 2 (Ankrd2) and Diabetes related ankyrin repeat protein DARP.
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| 1n0r, resolution 1.50Å () | |||||||||
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| Related: | 1n0q | ||||||||
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
Contents |
Structure
Using the N2A region of titin as bait in a yeast 2-hybrid screen of a skeletal muscle cDNA library cloned ANKRD1, which they called CARP. [1] full-length cDNA encoding ANKRD1 contains a nuclear localization signal, 4 tandem ankyrin-like repeats, multiple phosphorylation sites, and a PEST-rich region, which is typically found in rapidly degraded proteins.[2]
