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2jbt
From Proteopedia
(New page: 200px<br /> <applet load="2jbt" size="450" color="white" frame="true" align="right" spinBox="true" caption="2jbt, resolution 2.80Å" /> '''STRUCTURE OF THE MO...) |
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==About this Structure== | ==About this Structure== | ||
| - | 2JBT is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Acinetobacter_baumannii Acinetobacter baumannii]] with FMN and 4HP as [[http://en.wikipedia.org/wiki/ligands ligands]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2JBT OCA]]. | + | 2JBT is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Acinetobacter_baumannii Acinetobacter baumannii]] with FMN and 4HP as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2JBT OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: oxidoreductase]] | [[Category: oxidoreductase]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 12:16:10 2007'' |
Revision as of 10:11, 30 October 2007
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STRUCTURE OF THE MONOOXYGENASE COMPONENT OF P-HYDROXYPHENYLACETATE HYDROXYLASE FROM ACINETOBACTER BAUMANNII
Overview
p-Hydroxyphenylacetate hydroxylase from Acinetobacter baumannii is a, two-component system consisting of a NADH-dependent FMN reductase and a, monooxygenase (C2) that uses reduced FMN as substrate. The crystal, structures of C2 in the ligand-free and substrate-bound forms reveal a, preorganized pocket that binds reduced FMN without large conformational, changes. The Phe-266 side chain swings out to provide the space for, binding p-hydroxyphenylacetate that is oriented orthogonal to the flavin, ring. The geometry of the substrate-binding site of C2 is significantly, different from that of p-hydroxybenzoate hydroxylase, a single-component, flavoenzyme that catalyzes a similar reaction. The C2 overall structure, resembles the folding of medium-chain acyl-CoA dehydrogenase. An, outstanding ... [(full description)]
About this Structure
2JBT is a [Single protein] structure of sequence from [Acinetobacter baumannii] with FMN and 4HP as [ligands]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Structure of the monooxygenase component of a two-component flavoprotein monooxygenase., Alfieri A, Fersini F, Ruangchan N, Prongjit M, Chaiyen P, Mattevi A, Proc Natl Acad Sci U S A. 2007 Jan 23;104(4):1177-82. Epub 2007 Jan 16. PMID:17227849
Page seeded by OCA on Tue Oct 30 12:16:10 2007
