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2i1r
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(New page: 200px<br /><applet load="2i1r" size="350" color="white" frame="true" align="right" spinBox="true" caption="2i1r, resolution 2.2Å" /> '''Novel Thiazolones as ...)
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Revision as of 18:33, 29 January 2008
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Novel Thiazolones as HCV NS5B Polymerase Inhibitors: Further Designs, Synthesis, SAR and X-ray Complex Structure
Overview
Structure-activity relationships (SAR) of 1 against HCV NS5B polymerase, were described. SAR explorations and further structure-based design led to, the identifications of 2 and 3 as novel HCV NS5B inhibitors. X-ray, structure of 3 in complex with NS5B polymerase was obtained at a, resolution of 2.2A, and confirmed the design.
About this Structure
2I1R is a Single protein structure of sequence from Hepatitis c virus with as ligand. Active as RNA-directed RNA polymerase, with EC number 2.7.7.48 Full crystallographic information is available from OCA.
Reference
Novel thiazolones as HCV NS5B polymerase allosteric inhibitors: Further designs, SAR, and X-ray complex structure., Yan S, Larson G, Wu JZ, Appleby T, Ding Y, Hamatake R, Hong Z, Yao N, Bioorg Med Chem Lett. 2007 Jan 1;17(1):63-7. Epub 2006 Oct 4. PMID:17049849
Page seeded by OCA on Tue Jan 29 20:33:15 2008
