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2i39

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(New page: 200px<br /><applet load="2i39" size="350" color="white" frame="true" align="right" spinBox="true" caption="2i39, resolution 2.20&Aring;" /> '''Crystal structure of...)
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Revision as of 18:34, 29 January 2008

Image:2i39.gif

2i39, resolution 2.20Å

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Crystal structure of Vaccinia virus N1L protein

Overview

Poxviruses encode immuno-modulatory proteins capable of subverting host, defenses. The poxvirus vaccinia expresses a small 14-kDa protein, N1L, that is critical for virulence. We report the crystal structure of N1L, which reveals an unexpected but striking resemblance to host apoptotic, regulators of the B cell lymphoma-2 (Bcl-2) family. Although N1L lacks, detectable Bcl-2 homology (BH) motifs at the sequence level, we show that, N1L binds with high affinity to the BH3 peptides of pro-apoptotic Bcl-2, family proteins in vitro, consistent with a role for N1L in modulating, host antiviral defenses.

About this Structure

2I39 is a Single protein structure of sequence from Vaccinia virus with as ligand. Full crystallographic information is available from OCA.

Reference

Vaccinia virus N1L protein resembles a B cell lymphoma-2 (Bcl-2) family protein., Aoyagi M, Zhai D, Jin C, Aleshin AE, Stec B, Reed JC, Liddington RC, Protein Sci. 2007 Jan;16(1):118-24. Epub 2006 Nov 22. PMID:17123957

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