3qlz

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'''Unreleased structure'''
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[[Image:3qlz.jpg|left|200px]]
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The entry 3qlz is ON HOLD until Paper Publication
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{{STRUCTURE_3qlz| PDB=3qlz | SCENE= }}
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Authors: Paulsen, J.L., Bendel, S.D., Anderson, A.C.
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===Candida glabrata dihydrofolate reductase complexed with NADPH and 5-[3-(2,5-dimethoxyphenyl)prop-1-yn-1-yl]-6-propylpyrimidine-2,4-diamine (UCP130B)===
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Description: Candida glabrata dihydrofolate reductase complexed with NADPH and 5-[3-(2,5-dimethoxyphenyl)prop-1-yn-1-yl]-6-propylpyrimidine-2,4-diamine (UCP130B)
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{{ABSTRACT_PUBMED_21726415}}
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==About this Structure==
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[[3qlz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Candida_glabrata Candida glabrata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QLZ OCA].
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==Reference==
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<ref group="xtra">PMID:021726415</ref><references group="xtra"/>
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[[Category: Candida glabrata]]
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[[Category: Anderson, A C.]]
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[[Category: Bendel, S D.]]
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[[Category: Paulsen, J L.]]
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[[Category: Antifungal agent]]
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[[Category: Candida glabrata]]
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[[Category: Drug design]]
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[[Category: Enzyme inhibitor]]
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[[Category: Fungal protein]]
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[[Category: Model]]
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[[Category: Molecular structure]]
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[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
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[[Category: Structure-activity relationship]]
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[[Category: Tetrahydrofolate dehydrogenase]]

Revision as of 06:56, 20 July 2011

Image:3qlz.jpg

Template:STRUCTURE 3qlz

Candida glabrata dihydrofolate reductase complexed with NADPH and 5-[3-(2,5-dimethoxyphenyl)prop-1-yn-1-yl]-6-propylpyrimidine-2,4-diamine (UCP130B)

Template:ABSTRACT PUBMED 21726415

About this Structure

3qlz is a 2 chain structure with sequence from Candida glabrata. Full crystallographic information is available from OCA.

Reference

  • Paulsen JL, Bendel SD, Anderson AC. Crystal structures of Candida albicans dihydrofolate reductase bound to propargyl-linked antifolates reveal the flexibility of active site loop residues critical for ligand potency and selectivity. Chem Biol Drug Des. 2011 Jul 5. doi: 10.1111/j.1747-0285.2011.01169.x. PMID:21726415 doi:10.1111/j.1747-0285.2011.01169.x

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OCA

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