This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
Caspase
From Proteopedia
Michal Harel (Talk | contribs)
(New page: {{STRUCTURE_3d6f| PDB=3d6f | SIZE=300| SCENE= |right| CAPTION=CASP-1 complex with polypeptide inhibitor, 3d6f }} '''Caspase''' (CASP) are cysteine-aspartic proteases which funct...)
Next diff →
Revision as of 07:43, 24 July 2011
Template:STRUCTURE 3d6f
Caspase (CASP) are cysteine-aspartic proteases which function in apoptosis, necrosis and inflammation. Twelve CASP have been identified in human. CASP is synthesized as an inactive pro-CASP with a prodomain which is being cleaved off to render them active. The X-linked inhibitor of apoptosis protein (XIAP) with its baculoviral IAP repeat (BIR) domain is an inhibitor of CASP. CASP-1 cleaves precursor cytokine interleukin 1-β and interleukin 18 into mature protein. CASP-3 interacts with CASP-8 and CASP-9 during cell apoptosis.
Contents |
