Molecular Playground/Chymotrypsin
From Proteopedia
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<applet load='1wat' size='[450,338]' frame='true' align='right' | <applet load='1wat' size='[450,338]' frame='true' align='right' | ||
| - | caption='Structure of Alpha-Chymotrypsin | + | caption='Structure of Alpha-Chymotrypsin [[4cha]]' scene='User:Bradley_Duncan/Sandbox_1/Scene_1/2'/> |
Molecular Playground banner: Chymotrypsin is a digestive enzyme that breaks down proteins | Molecular Playground banner: Chymotrypsin is a digestive enzyme that breaks down proteins | ||
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| + | ==3D structures of chymotrypsin== | ||
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| + | [[Chymotrypsin]] | ||
===References=== | ===References=== | ||
You C-C, Agasti SS, De M, Knapp MJ, Rotello VM. Modulation of the Catalytic Behavior of α-Chymotrypsin at Monolayer-Protected Nanoparticle Surfaces. Journal of the American Chemical Society 2006; 128:14612-14618. | You C-C, Agasti SS, De M, Knapp MJ, Rotello VM. Modulation of the Catalytic Behavior of α-Chymotrypsin at Monolayer-Protected Nanoparticle Surfaces. Journal of the American Chemical Society 2006; 128:14612-14618. | ||
Current revision
One of the CBI Molecules being studied in the University of Massachusetts Amherst Chemistry-Biology Interface Program at UMass Amherst and on display at the Molecular Playground.
Chymotrypsin () is a proteolytic enzyme which cleaves peptide bonds. The enzyme shows selectively to peptides with aromatic sidechains on the carboxyl side of the peptide bond. This is due to a “hydrophobic pocket” near the active site of the enzyme. The protein also contains a large number of cationic residues.
In this depiction of the monomer , the cationic amino acid residues on the protein (blue) can interact with anionic, functionalized nanoparticles. After the nanoparticle-protein complex is formed, chymotrypsin then displays a preference for cationic substrates due to interaction with the anionic nanoparticle. The active site of chymotrypsin is shown in red.
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Molecular Playground banner: Chymotrypsin is a digestive enzyme that breaks down proteins
3D structures of chymotrypsin
References
You C-C, Agasti SS, De M, Knapp MJ, Rotello VM. Modulation of the Catalytic Behavior of α-Chymotrypsin at Monolayer-Protected Nanoparticle Surfaces. Journal of the American Chemical Society 2006; 128:14612-14618.
