2il9
From Proteopedia
OCA (Talk | contribs)
(New page: 200px<br /><applet load="2il9" size="350" color="white" frame="true" align="right" spinBox="true" caption="2il9, resolution 3.100Å" /> '''Crystal Structure o...)
Next diff →
Revision as of 18:42, 29 January 2008
|
Crystal Structure of Plautia Stali Intestine Virus Intergenic Region Internal Ribosome Entry Site Ribosomal Binding Domain RNA at 3.1 Angstroms
Overview
Canonical cap-dependent translation initiation requires a large number of, protein factors that act in a stepwise assembly process. In contrast, internal ribosomal entry sites (IRESs) are cis-acting RNAs that in some, cases completely supplant these factors by recruiting and activating the, ribosome using a single structured RNA. Here we present the crystal, structures of the ribosome-binding domain from a Dicistroviridae, intergenic region IRES at 3.1 angstrom resolution, providing a view of the, prefolded architecture of an all-RNA translation initiation apparatus., Docking of the structure into cryo-electron microscopy reconstructions of, an IRES-ribosome complex suggests a model for ribosome manipulation by a, dynamic IRES RNA.
About this Structure
2IL9 is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
Reference
Structural basis for ribosome recruitment and manipulation by a viral IRES RNA., Pfingsten JS, Costantino DA, Kieft JS, Science. 2006 Dec 1;314(5804):1450-4. Epub 2006 Nov 23. PMID:17124290
Page seeded by OCA on Tue Jan 29 20:42:51 2008
