Helicase
From Proteopedia
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| - | {{STRUCTURE_3fht| PDB=3fht | SIZE= | + | {{STRUCTURE_3fht| PDB=3fht | SIZE=400| SCENE= |right| CAPTION=Human dead box ATP-dependent RNA helicase DDX19B complex with RNA, glycerin, phosphphoaminophosphonic adenylate and Mg+2, [[3fht]] }} |
'''Helicase''' (Hel) is a motor protein which separates nucleic acid strands like DNA double helix or self-annealed RNA. They use ATP hydrolysis for energy. Hel falls into 5 superfamilies (SF1-SF5). Some Hel contain a Helicase and RNase D C terminal | '''Helicase''' (Hel) is a motor protein which separates nucleic acid strands like DNA double helix or self-annealed RNA. They use ATP hydrolysis for energy. Hel falls into 5 superfamilies (SF1-SF5). Some Hel contain a Helicase and RNase D C terminal | ||
| - | Domain (HRDC). The α-thalassemia and mental retardation X-linked syndrome helicase (ATRX ), contains an ATRX-Dnmt3-Dnmt3L (ADD) domain in which many disease-related mutations are found. | + | Domain (HRDC). The α-thalassemia and mental retardation X-linked syndrome helicase (ATRX ), contains an ATRX-Dnmt3-Dnmt3L (ADD) domain in which many disease-related mutations are found. For details of PcrA helicase see [[Molecular Playground/PcrA Helicase]]. |
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Revision as of 07:58, 27 July 2011
Helicase (Hel) is a motor protein which separates nucleic acid strands like DNA double helix or self-annealed RNA. They use ATP hydrolysis for energy. Hel falls into 5 superfamilies (SF1-SF5). Some Hel contain a Helicase and RNase D C terminal Domain (HRDC). The α-thalassemia and mental retardation X-linked syndrome helicase (ATRX ), contains an ATRX-Dnmt3-Dnmt3L (ADD) domain in which many disease-related mutations are found. For details of PcrA helicase see Molecular Playground/PcrA Helicase.
Contents |
3D structures of helicase
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Michal Harel, Alexander Berchansky, Wayne Decatur, Joel L. Sussman
