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Prolyl hydroxylase domain
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Michal Harel (Talk | contribs)
(New page: {{STRUCTURE_3hqu| PDB=3hqu | SIZE=400| SCENE= |right|CAPTION=PHD2 with Fe+2 complex with HIF 1 α C terminal and iodoisoquinolin inhibitor, 3hqu }} '''Prolyl hydroxylase domain''...)
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Revision as of 09:21, 27 July 2011
Prolyl hydroxylase domain (PHD) proteins mediate oxygen-dependent degradation of Hypoxia-inducible factor (HIF) α subunit. They include PHD1, PHD2 and PHD3. The PHD is a Fe+2/oxogluterate (2OG)-dependent enzyme.
