1oiz
From Proteopedia
(New page: 200px<br /> <applet load="1oiz" size="450" color="white" frame="true" align="right" spinBox="true" caption="1oiz, resolution 1.88Å" /> '''THE MOLECULAR BASIS...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1OIZ is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with TRT as [[http://en.wikipedia.org/wiki/ligand ligand]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1OIZ OCA]]. | + | 1OIZ is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with TRT as [[http://en.wikipedia.org/wiki/ligand ligand]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1OIZ OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: vitamin e]] | [[Category: vitamin e]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 12:19:36 2007'' |
Revision as of 10:14, 30 October 2007
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THE MOLECULAR BASIS OF VITAMIN E RETENTION: STRUCTURE OF HUMAN ALPHA-TOCOPHEROL TRANSFER PROTEIN
Overview
Alpha-tocopherol transfer protein (alpha-TTP) is a liver protein, responsible for the selective retention of alpha-tocopherol from dietary, vitamin E, which is a mixture of alpha, beta, gamma, and delta-tocopherols, and the corresponding tocotrienols. The alpha-TTP-mediated transfer of, alpha-tocopherol into nascent VLDL is the major determinant of plasma, alpha-tocopherol levels in humans. Mutations in the alpha-TTP gene have, been detected in patients suffering from low plasma alpha-tocopherol and, ataxia with isolated vitamin E deficiency (AVED). The crystal structure of, alpha-TTP reveals two conformations. In its closed tocopherol-charged, form, a mobile helical surface segment seals the hydrophobic binding, pocket. In the presence of detergents, an open conformation is observed, ... [(full description)]
About this Structure
1OIZ is a [Single protein] structure of sequence from [Homo sapiens] with TRT as [ligand]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
The molecular basis of vitamin E retention: structure of human alpha-tocopherol transfer protein., Meier R, Tomizaki T, Schulze-Briese C, Baumann U, Stocker A, J Mol Biol. 2003 Aug 15;331(3):725-34. PMID:12899840
Page seeded by OCA on Tue Oct 30 12:19:36 2007
Categories: Homo sapiens | Single protein | Baumann, U. | Meier, R. | Schulze-Briese, C. | Stocker, A. | Tomizaki, T. | TRT | Ataxia | Aved | Tocopherol | Transfer protein | Transport | Vitamin e
