3o5n

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Revision as of 05:05, 10 August 2011

Template:STRUCTURE 3o5n

Tetrahydroquinoline carboxylates are potent inhibitors of the Shank PDZ domain, a putative target in autism disorders

Template:ABSTRACT PUBMED 21626699

About this Structure

3o5n is a 8 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

• Saupe J, Roske Y, Schillinger C, Kamdem N, Radetzki S, Diehl A, Oschkinat H, Krause G, Heinemann U, Rademann J. Discovery, Structure-Activity Relationship Studies, and Crystal Structure of Nonpeptide Inhibitors Bound to the Shank3 PDZ Domain. ChemMedChem. 2011 May 27. doi: 10.1002/cmdc.201100094. PMID:21626699 doi:10.1002/cmdc.201100094