2oiu

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(New page: 200px<br /><applet load="2oiu" size="350" color="white" frame="true" align="right" spinBox="true" caption="2oiu, resolution 2.60&Aring;" /> '''L1 Ribozyme Ligase c...)
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Revision as of 19:11, 29 January 2008

Image:2oiu.gif

2oiu, resolution 2.60Å

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L1 Ribozyme Ligase circular adduct

Overview

Life originated, according to the RNA World hypothesis, from, self-replicating ribozymes that catalyzed ligation of RNA fragments. We, have solved the 2.6 angstrom crystal structure of a ligase ribozyme that, catalyzes regiospecific formation of a 5' to 3' phosphodiester bond, between the 5'-triphosphate and the 3'-hydroxyl termini of two RNA, fragments. Invariant residues form tertiary contacts that stabilize a, flexible stem of the ribozyme at the ligation site, where an essential, magnesium ion coordinates three phosphates. The structure of the active, site permits us to suggest how transition-state stabilization and a, general base may catalyze the ligation reaction required for prebiotic RNA, assembly.

About this Structure

2OIU is a Protein complex structure of sequences from [1] with as ligand. Full crystallographic information is available from OCA.

Reference

The structural basis of ribozyme-catalyzed RNA assembly., Robertson MP, Scott WG, Science. 2007 Mar 16;315(5818):1549-53. PMID:17363667

Page seeded by OCA on Tue Jan 29 21:11:38 2008

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