2pah
From Proteopedia
(New page: 200px<br /> <applet load="2pah" size="450" color="white" frame="true" align="right" spinBox="true" caption="2pah, resolution 3.1Å" /> '''TETRAMERIC HUMAN PHE...) |
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==About this Structure== | ==About this Structure== | ||
| - | 2PAH is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with FE as [[http://en.wikipedia.org/wiki/ligand ligand]]. The following page contains interesting information on the relation of 2PAH with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb61_1.html Phenylalanine Hydroxylase]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.16.1 1.14.16.1]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2PAH OCA]]. | + | 2PAH is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with FE as [[http://en.wikipedia.org/wiki/ligand ligand]]. The following page contains interesting information on the relation of 2PAH with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb61_1.html Phenylalanine Hydroxylase]]. Active as [[http://en.wikipedia.org/wiki/Phenylalanine_4-monooxygenase Phenylalanine 4-monooxygenase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.16.1 1.14.16.1]]. Structure known Active Site: FE. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2PAH OCA]]. |
==Reference== | ==Reference== | ||
Structure of tetrameric human phenylalanine hydroxylase and its implications for phenylketonuria., Fusetti F, Erlandsen H, Flatmark T, Stevens RC, J Biol Chem. 1998 Jul 3;273(27):16962-7. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9642259 9642259] | Structure of tetrameric human phenylalanine hydroxylase and its implications for phenylketonuria., Fusetti F, Erlandsen H, Flatmark T, Stevens RC, J Biol Chem. 1998 Jul 3;273(27):16962-7. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9642259 9642259] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| + | [[Category: Phenylalanine 4-monooxygenase]] | ||
[[Category: Phenylalanine Hydroxylase]] | [[Category: Phenylalanine Hydroxylase]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: phenylketonuria]] | [[Category: phenylketonuria]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 12:20:40 2007'' |
Revision as of 10:15, 30 October 2007
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TETRAMERIC HUMAN PHENYLALANINE HYDROXYLASE
Overview
Phenylalanine hydroxylase (PheOH) catalyzes the conversion of, L-phenylalanine to L-tyrosine, the rate-limiting step in the oxidative, degradation of phenylalanine. Mutations in the human PheOH gene cause, phenylketonuria, a common autosomal recessive metabolic disorder that in, untreated patients often results in varying degrees of mental retardation., We have determined the crystal structure of human PheOH (residues, 118-452). The enzyme crystallizes as a tetramer with each monomer, consisting of a catalytic and a tetramerization domain. The, tetramerization domain is characterized by the presence of a domain, swapping arm that interacts with the other monomers forming an, antiparallel coiled-coil. The structure is the first report of a, tetrameric PheOH and displays an overall ... [(full description)]
About this Structure
2PAH is a [Single protein] structure of sequence from [Homo sapiens] with FE as [ligand]. The following page contains interesting information on the relation of 2PAH with [Phenylalanine Hydroxylase]. Active as [Phenylalanine 4-monooxygenase], with EC number [1.14.16.1]. Structure known Active Site: FE. Full crystallographic information is available from [OCA].
Reference
Structure of tetrameric human phenylalanine hydroxylase and its implications for phenylketonuria., Fusetti F, Erlandsen H, Flatmark T, Stevens RC, J Biol Chem. 1998 Jul 3;273(27):16962-7. PMID:9642259
Page seeded by OCA on Tue Oct 30 12:20:40 2007
