Phenylethanolamine N-methyltransferase
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[[Image:3kpj.jpg|left|200px|thumb|Crystal Structure of Phenylethanolamine N-methyltransferase [[3kpj]]]] | [[Image:3kpj.jpg|left|200px|thumb|Crystal Structure of Phenylethanolamine N-methyltransferase [[3kpj]]]] | ||
| - | {{STRUCTURE_3kpj| PDB=3kpj | SIZE=300| SCENE= |right|CAPTION=Phenylethanolamine N-methyltransferase [[3kpj]] }} | + | {{STRUCTURE_3kpj| PDB=3kpj | SIZE=300| SCENE= |right|CAPTION=Phenylethanolamine N-methyltransferase with adenosyl homocysteine complex with phosphate ions [[3kpj]] }} |
[[Phenylethanolamine N-methyltransferase]] (PNMT) catalyzes the conversion of norepinephrine (noradrenaline) to epinephrine (adrenaline). This is the last step in the conversion of tyrosine to adrenaline. S-adenosyl-L-homocysteine (AdoHcy) by itself or with other ligands are inhibitors of PNMT. The images at the left and at the right correspond to one representative PNMT, ''i.e.'' the crystal structure of Phenylethanolamine N-methyltransferase ([[3kpj]]). | [[Phenylethanolamine N-methyltransferase]] (PNMT) catalyzes the conversion of norepinephrine (noradrenaline) to epinephrine (adrenaline). This is the last step in the conversion of tyrosine to adrenaline. S-adenosyl-L-homocysteine (AdoHcy) by itself or with other ligands are inhibitors of PNMT. The images at the left and at the right correspond to one representative PNMT, ''i.e.'' the crystal structure of Phenylethanolamine N-methyltransferase ([[3kpj]]). | ||
Revision as of 07:00, 15 August 2011
Phenylethanolamine N-methyltransferase (PNMT) catalyzes the conversion of norepinephrine (noradrenaline) to epinephrine (adrenaline). This is the last step in the conversion of tyrosine to adrenaline. S-adenosyl-L-homocysteine (AdoHcy) by itself or with other ligands are inhibitors of PNMT. The images at the left and at the right correspond to one representative PNMT, i.e. the crystal structure of Phenylethanolamine N-methyltransferase (3kpj).
3D Structures of Phenylethanolamine N-methyltransferase
3kpj – hPNMT+AdoHcy – human
3kpu, 3kpv, 3kpw, 3kpy, 3kqm, 3kqo, 3kqp, 3kqq, 3kqs, 3kqt, 3kqv, 3kqw, 3kqy, 3kr0, 3kr1, 3kr2, 3hcb, 3hcc, 3hcf, 2ony, 2g70, 2g71, 2g8n, 2an5, 1yz3, 1n7i, 1n7j, 1hnn - hPNMT+AdoHcy+ligand
3hca, 3hce, 2obf, 2onz, 2obp - hPNMT (mutant)+AdoHcy+ligand
3hcd - hPNMT+AdoHcy+noradrenaline
2g72 - hPNMT+AdoMet+ligand
2an3 - hPNMT+AdoHcy+substrate analog
2an4 - hPNMT+AdoHcy+octopamine
