2bhr
From Proteopedia
(New page: 200px<br /> <applet load="2bhr" size="450" color="white" frame="true" align="right" spinBox="true" caption="2bhr, resolution 2.8Å" /> '''DENGUE VIRUS RNA HEL...) |
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==About this Structure== | ==About this Structure== | ||
| - | 2BHR is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/ | + | 2BHR is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Dengue_virus_type_3 Dengue virus type 3]] with SO4 as [[http://en.wikipedia.org/wiki/ligand ligand]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2BHR OCA]]. |
==Reference== | ==Reference== | ||
Structure of the Dengue virus helicase/nucleoside triphosphatase catalytic domain at a resolution of 2.4 A., Xu T, Sampath A, Chao A, Wen D, Nanao M, Chene P, Vasudevan SG, Lescar J, J Virol. 2005 Aug;79(16):10278-88. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16051821 16051821] | Structure of the Dengue virus helicase/nucleoside triphosphatase catalytic domain at a resolution of 2.4 A., Xu T, Sampath A, Chao A, Wen D, Nanao M, Chene P, Vasudevan SG, Lescar J, J Virol. 2005 Aug;79(16):10278-88. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16051821 16051821] | ||
| - | [[Category: Dengue virus type | + | [[Category: Dengue virus type 3]] |
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Chao, A.]] | [[Category: Chao, A.]] | ||
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[[Category: rna helicase]] | [[Category: rna helicase]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 12:21:46 2007'' |
Revision as of 10:17, 30 October 2007
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DENGUE VIRUS RNA HELICASE
Overview
Dengue fever is an important emerging public health concern, with several, million viral infections occurring annually, for which no effective, therapy currently exists. The NS3 protein from Dengue virus is a, multifunctional protein of 69 kDa, endowed with protease, helicase, and, nucleoside 5'-triphosphatase (NTPase) activities. Thus, NS3 plays an, important role in viral replication and represents a very interesting, target for the development of specific antiviral inhibitors. We present, the structure of an enzymatically active fragment of the Dengue virus, NTPase/helicase catalytic domain to 2.4 A resolution. The structure is, composed of three domains, displays an asymmetric distribution of charges, on its surface, and contains a tunnel large enough to accommodate, single-stranded ... [(full description)]
About this Structure
2BHR is a [Single protein] structure of sequence from [Dengue virus type 3] with SO4 as [ligand]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Structure of the Dengue virus helicase/nucleoside triphosphatase catalytic domain at a resolution of 2.4 A., Xu T, Sampath A, Chao A, Wen D, Nanao M, Chene P, Vasudevan SG, Lescar J, J Virol. 2005 Aug;79(16):10278-88. PMID:16051821
Page seeded by OCA on Tue Oct 30 12:21:46 2007
