This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
3sfk
From Proteopedia
| Line 1: | Line 1: | ||
| - | [[Image:3sfk. | + | [[Image:3sfk.png|left|200px]] |
<!-- | <!-- | ||
Revision as of 06:42, 17 August 2011
Crystal structure of Plasmodium falciparum dihydroorotate dehydrogenase bound with Inhibitor DSM267
Template:ABSTRACT PUBMED 21696174
About this Structure
3sfk is a 1 chain structure with sequence from Plasmodium falciparum 3d7. Full crystallographic information is available from OCA.
Reference
- Coteron JM, Marco M, Esquivias J, Deng X, White KL, White J, Koltun M, El Mazouni F, Kokkonda S, Katneni K, Bhamidipati R, Shackleford D, Barturen I, Ferrer S, Jimenez-Diaz MB, Gamo FJ, Goldsmith EJ, Charman B, Bathurst I, Floyd D, Matthews D, Burrows JN, Rathod PK, Charman SA, Phillips MA. Structure-guided lead optimization of triazolopyrimidine-ring substituents identifies potent Plasmodium falciparum dihydroorotate dehydrogenase inhibitors with clinical candidate potential. J Med Chem. 2011 Jun 22. PMID:21696174 doi:10.1021/jm200592f
Categories: Dihydroorotate dehydrogenase | Plasmodium falciparum 3d7 | Deng, X. | Phillips, M. | Alpha beta barrel oxidoreductase | Alpha beta fold | Flavoprotein | Fmn | Inhibitor dsm267 | Mitochondrion inner membrane | Oxidoreductase-oxidoreductase inhibitor complex | Plasmodium falciparum membrane mitochondrion | Pyrimidine biosynthesis
