Response regulator
From Proteopedia
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== 3D Structures of response regulator == | == 3D Structures of response regulator == | ||
| - | [[3sft]] – TmCheB methyltransferase catalytic domain – Thermotoga maritima<br /> | + | [[3sft]] – TmCheB methyltransferase catalytic domain – ''Thermotoga maritima''<br /> |
[[1p2f]] – TmDrrB<br /> | [[1p2f]] – TmDrrB<br /> | ||
[[3gl9]], [[3dgf]] – TmRR<br /> | [[3gl9]], [[3dgf]] – TmRR<br /> | ||
| - | [[3snk]] – CheY-like – Mesorhizobium loti<br /> | + | [[3snk]] – CheY-like – ''Mesorhizobium loti''<br /> |
| - | [[3crn]], [[3cg4]] - CheY-like – Methanospirillum hungatei<br /> | + | [[3crn]], [[3cg4]] - CheY-like – ''Methanospirillum hungatei''<br /> |
[[1ixm]] – BsSpo0B<br /> | [[1ixm]] – BsSpo0B<br /> | ||
[[1nat]] – BsSPo0F<br /> | [[1nat]] – BsSPo0F<br /> | ||
[[1srr]] - BsSPo0F (mutant) <br /> | [[1srr]] - BsSPo0F (mutant) <br /> | ||
| - | [[3p3q]] – McMmoQ (mutant) – Methylococcus capsulatus<br /> | + | [[3p3q]] – McMmoQ (mutant) – ''Methylococcus capsulatus''<br /> |
[[3ljx]] – McMmoQ residues 20-298<br /> | [[3ljx]] – McMmoQ residues 20-298<br /> | ||
| - | [[3n0r]] – CvPhyR – Caulobacter vibrioides<br /> | + | [[3n0r]] – CvPhyR – ''Caulobacter vibrioides''<br /> |
[[1m5t]], [[1m5u]] - CvDivK<br /> | [[1m5t]], [[1m5u]] - CvDivK<br /> | ||
| - | [[3n53]] – RR – Pelobacter carbinolicus<br /> | + | [[3n53]] – RR – ''Pelobacter carbinolicus''<br /> |
| - | [[3nhm]] – MxRR – Myxococcus xanthus<br /> | + | [[3nhm]] – MxRR – ''Myxococcus xanthus''<br /> |
| - | [[3kto]] - RR – Pseudoalteromonas atlantica<br /> | + | [[3kto]] - RR – ''Pseudoalteromonas atlantica''<br /> |
| - | [[3f7a]], [[3eq2]] – PaRssB – Pseudomonas aeruginosa<br /> | + | [[3f7a]], [[3eq2]] – PaRssB – ''Pseudomonas aeruginosa''<br /> |
[[3es2]] – PaRssB phosphatase domain<br /> | [[3es2]] – PaRssB phosphatase domain<br /> | ||
[[3i5b]] – PaWpsR GGDEF domain<br /> | [[3i5b]] – PaWpsR GGDEF domain<br /> | ||
[[3i5c]] - PaWpsR GGDEF domain/GCN4 leucine zipper<br /> | [[3i5c]] - PaWpsR GGDEF domain/GCN4 leucine zipper<br /> | ||
| - | [[1yio]], [[1zn2]] – PfStyR – Pseudomonas fluorescens<br /> | + | [[1yio]], [[1zn2]] – PfStyR – ''Pseudomonas fluorescens''<br /> |
| - | [[3hdv]] – RR – Pseudomonas putida<br /> | + | [[3hdv]] – RR – ''Pseudomonas putida''<br /> |
| - | [[3i5a]] – WpsR – Pseudomonas syringae<br /> | + | [[3i5a]] – WpsR – ''Pseudomonas syringae''<br /> |
| - | [[3heb]] – CheY – Rhodospirillum rubrum<br /> | + | [[3heb]] – CheY – ''Rhodospirillum rubrum''<br /> |
| - | [[3eqz]] – CpRR – Colwellia psychrerythraea<br /> | + | [[3eqz]] – CpRR – ''Colwellia psychrerythraea''<br /> |
| - | [[2zay]] – RR residues 150-285 – Desulfuromonas acetoxidans<br /> | + | [[2zay]] – RR residues 150-285 – ''Desulfuromonas acetoxidans''<br /> |
| - | [[2rdm]] – RR (mutant) – Sinorhizobium medicae<br /> | + | [[2rdm]] – RR (mutant) – ''Sinorhizobium medicae''<br /> |
| - | [[1xhe]] – EcArcA (mutant) - Escherichia coli<br /> | + | [[1xhe]] – EcArcA (mutant) - ''Escherichia coli''<br /> |
[[1jbe]] - EcCheY<br /> | [[1jbe]] - EcCheY<br /> | ||
[[1nxo]], [[1nxp]], [[1nxs]], [[1nxt]], [[1nxv]], [[1nxw]], [[1nxx]] – SpRR MICA receiver domain<br /> | [[1nxo]], [[1nxp]], [[1nxs]], [[1nxt]], [[1nxv]], [[1nxw]], [[1nxx]] – SpRR MICA receiver domain<br /> | ||
| - | [[2gwr]] – MtMtrA - Mycobacterium tuberculosis<br /> | + | [[2gwr]] – MtMtrA - ''Mycobacterium tuberculosis''<br /> |
[[1ys6]] – MtPrrA<br /> | [[1ys6]] – MtPrrA<br /> | ||
| - | [[1k66]] – ToRcpB – Tolypothrix<br /> | + | [[1k66]] – ToRcpB – ''Tolypothrix''<br /> |
[[1k68]] – ToRcpA<br /> | [[1k68]] – ToRcpA<br /> | ||
| - | [[3p01]] – RR residues 134-315 – Nostoc<br /> | + | [[3p01]] – RR residues 134-315 – ''Nostoc''<br /> |
| - | [[3ilh]] – RR – Cytophaga hutchinsonii<br /> | + | [[3ilh]] – RR – ''Cytophaga hutchinsonii''<br /> |
[[3c3w]] – MtDosR <br /> | [[3c3w]] – MtDosR <br /> | ||
| - | [[2qvg]] – RR – Legionella pneumophila<br /> | + | [[2qvg]] – RR – ''Legionella pneumophila''<br /> |
| - | [[2qr3]] – RR – Bacterioides fragilis<br /> | + | [[2qr3]] – RR – ''Bacterioides fragilis''<br /> |
===Response regulator signal receiving domain=== | ===Response regulator signal receiving domain=== | ||
[[2qxy]] – TmRR <br /> | [[2qxy]] – TmRR <br /> | ||
| - | [[3i42]] - CheY-like – Methylobacillus flagellatus<br /> | + | [[3i42]] - CheY-like – ''Methylobacillus flagellatus''<br /> |
[[2zwm]]– BsYycF <br /> | [[2zwm]]– BsYycF <br /> | ||
[[1mvo]] - BsPhoP <br /> | [[1mvo]] - BsPhoP <br /> | ||
[[3gkg]], [[2i6f]] – MxFrzS <br /> | [[3gkg]], [[2i6f]] – MxFrzS <br /> | ||
[[2nt3]], [[2nt4]] - MxFrzS (mutant) <br /> | [[2nt3]], [[2nt4]] - MxFrzS (mutant) <br /> | ||
| - | [[3lte]] – RR – Bermanella marisrubri<br /> | + | [[3lte]] – RR – ''Bermanella marisrubri''<br /> |
[[3hv2]] – PfRR <br /> | [[3hv2]] – PfRR <br /> | ||
| - | [[3kht]] – RR – Hahella chejuensis<br /> | + | [[3kht]] – RR – ''Hahella chejuensis''<br /> |
| - | [[3jte]] – CtRR - Clostridium thermocellum<br /> | + | [[3jte]] – CtRR - ''Clostridium thermocellum''<br /> |
[[3cnb]] – CpRR <br /> | [[3cnb]] – CpRR <br /> | ||
| - | [[3c3m]] – RR – Methanoculleus marisnigri<br /> | + | [[3c3m]] – RR – ''Methanoculleus marisnigri''<br /> |
| - | [[2qsj]] – LuxR – Silicibacter pomeroyi<br /> | + | [[2qsj]] – LuxR – ''Silicibacter pomeroyi''<br /> |
| - | [[2pln]] – RR – Helicobacter pylori<br /> | + | [[2pln]] – RR – ''Helicobacter pylori''<br /> |
[[2jb9]], [[2jba]] – EcPhoB (mutant) <br /> | [[2jb9]], [[2jba]] – EcPhoB (mutant) <br /> | ||
[[3lua]] – CtRR<br /> | [[3lua]] – CtRR<br /> | ||
| - | [[3lsg]] – YesN – Fusobacterium nucleatum<br /> | + | [[3lsg]] – YesN – ''Fusobacterium nucleatum''<br /> |
| - | [[3cz5]] – LuxR – Aurantimonas<br /> | + | [[3cz5]] – LuxR – ''Aurantimonas''<br /> |
| - | [[2qzj]] – RR – Clostridium difficile<br /> | + | [[2qzj]] – RR – ''Clostridium difficile''<br /> |
[[1a04]], [[1rnl]] – EcNarL | [[1a04]], [[1rnl]] – EcNarL | ||
===Response regulator DNA-binding domain=== | ===Response regulator DNA-binding domain=== | ||
| - | [[2zxj]] - SaYycF - Staphylococcus aureus<br /> | + | [[2zxj]] - SaYycF - ''Staphylococcus aureus''<br /> |
[[2rnj]] - SaVraR - NMR<BR /> | [[2rnj]] - SaVraR - NMR<BR /> | ||
| - | [[2hwv]] – VicR – Enterococcus faecalis<br /> | + | [[2hwv]] – VicR – ''Enterococcus faecalis''<br /> |
| - | [[1umq]] – PrrA – Rhodobacter sphaeroides – NMR<BR /> | + | [[1umq]] – PrrA – ''Rhodobacter sphaeroides'' – NMR<BR /> |
[[3c57]] – MtDosR <br /> | [[3c57]] – MtDosR <br /> | ||
[[2pmu]] – MtPhoP | [[2pmu]] – MtPhoP | ||
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[[3a0u]] - TmTrrA + Mg + BeF3<br /> | [[3a0u]] - TmTrrA + Mg + BeF3<br /> | ||
[[3a10]] - TmTrrA (mutant) + Mg + BeF3<br /> | [[3a10]] - TmTrrA (mutant) + Mg + BeF3<br /> | ||
| - | [[3rqi]] – RR + phosphorylated aspartic acid + citrate + Ca – Burkholderia pseudomallei<br /> | + | [[3rqi]] – RR + phosphorylated aspartic acid + citrate + Ca – ''Burkholderia pseudomallei''<br /> |
| - | [[3q15]] – BsRapH + sporulation initiation phosphotransferase – Bacillus subtilis<br /> | + | [[3q15]] – BsRapH + sporulation initiation phosphotransferase – ''Bacillus subtilis''<br /> |
| - | [[3m6m]] – RpfF residues 400-541 + RpfF protein REC domain – Xanthomonas campestris<br /> | + | [[3m6m]] – RpfF residues 400-541 + RpfF protein REC domain – ''Xanthomonas campestris''<br /> |
[[1mav]], [[1mb0]], [[1mb3]] – CvDivK + metal ion<br /> | [[1mav]], [[1mb0]], [[1mb3]] – CvDivK + metal ion<br /> | ||
| - | [[2wb4]] – PleD + cyclic diguanosine monophosphate + BeF3 – Caulobacter crescentus<br /> | + | [[2wb4]] – PleD + cyclic diguanosine monophosphate + BeF3 – ''Caulobacter crescentus''<br /> |
[[2v0n]] – CvPleD residues 2-454 + cyclic diguanosine monophosphate + GTP + BeF3<br /> | [[2v0n]] – CvPleD residues 2-454 + cyclic diguanosine monophosphate + GTP + BeF3<br /> | ||
| - | [[3hzh]] – CheX + CheY + Mg + BeF3 – Borrelia burgdorferi<br /> | + | [[3hzh]] – CheX + CheY + Mg + BeF3 – ''Borrelia burgdorferi''<br /> |
[[1xhf]] - EcArcA (mutant) + BeF3<br /> | [[1xhf]] - EcArcA (mutant) + BeF3<br /> | ||
| - | [[2a9o]], [[2a9p]], [[2a9q]], [[2a9r]] – SpYycF + BeF3 – Streptococcus pneumoniae<br /> | + | [[2a9o]], [[2a9p]], [[2a9q]], [[2a9r]] – SpYycF + BeF3 – ''Streptococcus pneumoniae''<br /> |
[[1ys7]] – MtPrrA + Mg<br /> | [[1ys7]] – MtPrrA + Mg<br /> | ||
| - | [[1jlk]], [[1i3c]] – Rcp1 + Mn]] - Synechocystis<br /> | + | [[1jlk]], [[1i3c]] – Rcp1 + Mn]] - ''Synechocystis''<br /> |
[[3dge]] – TmRR + SP cytoplasmic domain<br /> | [[3dge]] – TmRR + SP cytoplasmic domain<br /> | ||
[[3a0r]] – TmTrrA + histidine kinase ThkA<br /> | [[3a0r]] – TmTrrA + histidine kinase ThkA<br /> | ||
Revision as of 09:25, 18 August 2011
Response regulators (RR) are part of the two-component signal transduction systems which enable bacteria to sense and respond to a wide range of environments. Two-component RR is a complex of histidine kinase (sensor protein SP) and RR. The RR act as phosphorylation-activated switches. Most RR consist of N terminal shich is the signal receiving domain and C terminal which is the DNA-binding domain.
Contents |
3D Structures of response regulator
3sft – TmCheB methyltransferase catalytic domain – Thermotoga maritima
1p2f – TmDrrB
3gl9, 3dgf – TmRR
3snk – CheY-like – Mesorhizobium loti
3crn, 3cg4 - CheY-like – Methanospirillum hungatei
1ixm – BsSpo0B
1nat – BsSPo0F
1srr - BsSPo0F (mutant)
3p3q – McMmoQ (mutant) – Methylococcus capsulatus
3ljx – McMmoQ residues 20-298
3n0r – CvPhyR – Caulobacter vibrioides
1m5t, 1m5u - CvDivK
3n53 – RR – Pelobacter carbinolicus
3nhm – MxRR – Myxococcus xanthus
3kto - RR – Pseudoalteromonas atlantica
3f7a, 3eq2 – PaRssB – Pseudomonas aeruginosa
3es2 – PaRssB phosphatase domain
3i5b – PaWpsR GGDEF domain
3i5c - PaWpsR GGDEF domain/GCN4 leucine zipper
1yio, 1zn2 – PfStyR – Pseudomonas fluorescens
3hdv – RR – Pseudomonas putida
3i5a – WpsR – Pseudomonas syringae
3heb – CheY – Rhodospirillum rubrum
3eqz – CpRR – Colwellia psychrerythraea
2zay – RR residues 150-285 – Desulfuromonas acetoxidans
2rdm – RR (mutant) – Sinorhizobium medicae
1xhe – EcArcA (mutant) - Escherichia coli
1jbe - EcCheY
1nxo, 1nxp, 1nxs, 1nxt, 1nxv, 1nxw, 1nxx – SpRR MICA receiver domain
2gwr – MtMtrA - Mycobacterium tuberculosis
1ys6 – MtPrrA
1k66 – ToRcpB – Tolypothrix
1k68 – ToRcpA
3p01 – RR residues 134-315 – Nostoc
3ilh – RR – Cytophaga hutchinsonii
3c3w – MtDosR
2qvg – RR – Legionella pneumophila
2qr3 – RR – Bacterioides fragilis
Response regulator signal receiving domain
2qxy – TmRR
3i42 - CheY-like – Methylobacillus flagellatus
2zwm– BsYycF
1mvo - BsPhoP
3gkg, 2i6f – MxFrzS
2nt3, 2nt4 - MxFrzS (mutant)
3lte – RR – Bermanella marisrubri
3hv2 – PfRR
3kht – RR – Hahella chejuensis
3jte – CtRR - Clostridium thermocellum
3cnb – CpRR
3c3m – RR – Methanoculleus marisnigri
2qsj – LuxR – Silicibacter pomeroyi
2pln – RR – Helicobacter pylori
2jb9, 2jba – EcPhoB (mutant)
3lua – CtRR
3lsg – YesN – Fusobacterium nucleatum
3cz5 – LuxR – Aurantimonas
2qzj – RR – Clostridium difficile
1a04, 1rnl – EcNarL
Response regulator DNA-binding domain
2zxj - SaYycF - Staphylococcus aureus
2rnj - SaVraR - NMR
2hwv – VicR – Enterococcus faecalis
1umq – PrrA – Rhodobacter sphaeroides – NMR
3c57 – MtDosR
2pmu – MtPhoP
Response regulator complex
3nnn – TmDrrD signal receiving domain + BeF3
3nns – TmDrrB signal receiving domain + BeF3
3a0u - TmTrrA + Mg + BeF3
3a10 - TmTrrA (mutant) + Mg + BeF3
3rqi – RR + phosphorylated aspartic acid + citrate + Ca – Burkholderia pseudomallei
3q15 – BsRapH + sporulation initiation phosphotransferase – Bacillus subtilis
3m6m – RpfF residues 400-541 + RpfF protein REC domain – Xanthomonas campestris
1mav, 1mb0, 1mb3 – CvDivK + metal ion
2wb4 – PleD + cyclic diguanosine monophosphate + BeF3 – Caulobacter crescentus
2v0n – CvPleD residues 2-454 + cyclic diguanosine monophosphate + GTP + BeF3
3hzh – CheX + CheY + Mg + BeF3 – Borrelia burgdorferi
1xhf - EcArcA (mutant) + BeF3
2a9o, 2a9p, 2a9q, 2a9r – SpYycF + BeF3 – Streptococcus pneumoniae
1ys7 – MtPrrA + Mg
1jlk, 1i3c – Rcp1 + Mn]] - Synechocystis
3dge – TmRR + SP cytoplasmic domain
3a0r – TmTrrA + histidine kinase ThkA
1zg1, 1zg5, 1je8 – EcNarL DNA-binding domain + DNA
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Michal Harel, Joel L. Sussman, Alexander Berchansky, Jaime Prilusky
