3php
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(New page: 200px<br /><applet load="3php" size="350" color="white" frame="true" align="right" spinBox="true" caption="3php" /> '''STRUCTURE OF THE 3' HAIRPIN OF THE TYMV PSEU...)
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Revision as of 19:41, 29 January 2008
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STRUCTURE OF THE 3' HAIRPIN OF THE TYMV PSEUDOKNOT: PREFORMATION IN RNA FOLDING
Overview
The solution structure of an RNA-hairpin present in the pseudoknot, which, is found at the 3'-terminus of turnip yellow mosaic virus genomic RNA, has, been solved by nuclear magnetic resonance spectroscopy. The loop, which, contains the sequence 5'-GGGUCA-3', was found to be highly structured and, contrary to expectations, does not attain its stability through GA or GC, base pair formation but by triple interactions between the tilted, adenosine and the minor groove sides of the first two guanosines., Interestingly, a very similar conformation was found for the cognate, pseudoknot, implying that the 3'-hairpin is preformed for folding into a, pseudoknotted structure. These findings suggest a mechanism of, 'predetermined-fit' as a principle in RNA folding.
About this Structure
3PHP is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
Reference
Structure of the 3'-hairpin of the TYMV pseudoknot: preformation in RNA folding., Kolk MH, van der Graaf M, Fransen CT, Wijmenga SS, Pleij CW, Heus HA, Hilbers CW, EMBO J. 1998 Dec 15;17(24):7498-504. PMID:9857204
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